Detailed information of TA system TA148626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3456220..3457796
• Replicon: chromosome
• Accession: NZ_CP047981
• Organism: Aeromonas caviae strain 1607-10029

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GWC92_RS16150
• Protein ID: WP_113068876.1
• Coordinates: 3456474..3457796 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GWC92_RS16145
• Protein ID: WP_113068875.1
• Coordinates: 3456220..3456474 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWC92_RS16130	3451567..3452356	-	790	Protein_3114	IS5 family transposase	-
GWC92_RS16135	3452527..3454248	+	1722	WP_113068873.1	AAA family ATPase	-
GWC92_RS16140	3454251..3455876	+	1626	WP_113068874.1	ATP-dependent helicase	-
GWC92_RS16145	3456220..3456474	+	255	WP_113068875.1	helix-turn-helix domain-containing protein	Antitoxin
GWC92_RS16150	3456474..3457796	+	1323	WP_113068876.1	type II toxin-antitoxin system HipA family toxin	Toxin
GWC92_RS16155	3458221..3459690	-	1470	WP_113068877.1	hypothetical protein	-
GWC92_RS16160	3459635..3462199	-	2565	WP_113068878.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3450951..3467528	16577
	-	flank	IS/Tn	-	-	3451498..3452130	632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49530.09 Da
• Isoelectric Point: 8.0907

>T148626 WP_113068876.1 NZ_CP047981:3456474-3457796 [Aeromonas caviae]
MANLWVYMNGYRVGTFTMTTSGAHQFQYDESWVTLPGSRPISLSMPLRQQCYRGDEPYNFFGNLLPDNLEVKNRVVARYQ
ANSTQSFDLLSCIGQDCVGALQLVAQGAPTPDVKRIECKPLSDAELEHILTSYQQGIPLGMVREVEDFRISIAGAQEKTA
LLYRDNRWYLPSAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFIMQVGKIKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSVRKYESHGGPSIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPGGSFRLTPFYDILSMYPAFGGRGLHPRDAKLAMGLTASKGKIYAIDHIFPCHFYRTAKAVGFEQAKMKRIIAEFIGNL
DMVISNVRAKLPDTFPPRITESILKGLTTRIQRLDLSSIE

Nucleotide

• Length: 1323 bp

>T148626 NZ_CP063804:2825505-2825918 [Mycobacterium orygis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 8.4810

>AT148626 WP_113068875.1 NZ_CP047981:3456220-3456474 [Aeromonas caviae]
MKVTSAKQLSAYLKDARLLQKYSQGKVADKVGIRQDTVSNFELNPESTKLDTLFKILAALELSLDIKPRTDPPDSPSSGW
KEEW

Nucleotide

• Length: 255 bp

>AT148626 NZ_CP063804:2825957-2826214 [Mycobacterium orygis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA