Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 199615..200268 Replicon chromosome
Accession NZ_CP047972
Organism Kyrpidia spormannii strain COOX1

Toxin (Protein)


Gene name mazF Uniprot ID D5WSA7
Locus tag GWK42_RS01120 Protein ID WP_013074285.1
Coordinates 199918..200268 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K8N2G8
Locus tag GWK42_RS01115 Protein ID WP_041303528.1
Coordinates 199615..199914 (+) Length 100 a.a.

Genomic Context

GWK42_RS01095GWK42_RS01100GWK42_RS01105GWK42_RS01115GWK42_RS01120GWK42_RS01125GWK42_RS01130GWK42_RS01135GWK42_RS01140GWK42_RS01110GWK42_RS01145
Location: 194902..195294 (393 bp)
Type: Others
Protein ID: WP_170086728.1
Location: 195426..196937 (1512 bp)
Type: Others
Protein ID: WP_170084684.1
Location: 197018..198010 (993 bp)
Type: Others
Protein ID: WP_170084685.1
Location: 199615..199914 (300 bp)
Type: Antitoxin
Protein ID: WP_041303528.1
Location: 199918..200268 (351 bp)
Type: Toxin
Protein ID: WP_013074285.1
Location: 200327..201586 (1260 bp)
Type: Others
Protein ID: WP_170084687.1
Location: 201742..202482 (741 bp)
Type: Others
Protein ID: WP_170084688.1
Location: 202774..202995 (222 bp)
Type: Others
Protein ID: WP_013074288.1
Location: 203031..203264 (234 bp)
Type: Others
Protein ID: WP_170084689.1
Location: 198021..199112 (1092 bp)
Type: Others
Protein ID: WP_170084686.1
Location: 203381..203974 (594 bp)
Type: Others
Protein ID: WP_100666597.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GWK42_RS01095194902..195294+393WP_170086728.1holo-ACP synthase-
GWK42_RS01100195426..196937+1512WP_170084684.1NAD(P)H-hydrate dehydratase-
GWK42_RS01105197018..198010+993WP_170084685.1outer membrane lipoprotein carrier protein LolA-
GWK42_RS01110198021..199112-1092WP_170084686.1cation diffusion facilitator family transporter-
GWK42_RS01115199615..199914+300WP_041303528.1CopG family ribbon-helix-helix proteinAntitoxin
GWK42_RS01120199918..200268+351WP_013074285.1type II toxin-antitoxin system PemK/MazF family toxinToxin
GWK42_RS01125200327..201586+1260WP_170084687.1adenosylhomocysteinase-
GWK42_RS01130201742..202482+741WP_170084688.1gamma-glutamyl-gamma-aminobutyrate hydrolase family protein-
GWK42_RS01135202774..202995+222WP_013074288.1DUF1659 domain-containing protein-
GWK42_RS01140203031..203264+234WP_170084689.1DUF2922 domain-containing protein-
GWK42_RS01145203381..203974-594WP_100666597.1DedA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-53)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12906.94 Da        Isoelectric Point: 5.6976

>T148618 WP_013074285.1 NZ_CP047972:199918-200268 [Kyrpidia spormannii]
VNIKRGDIFFANLSPVVGSEQGGFRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGLDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMSKVNESLMISLGLIDF

Download         Length: 351 bp

>T148618 NZ_CP063804:c2207698-2207138 [Mycobacterium orygis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11329.99 Da        Isoelectric Point: 4.9577

>AT148618 WP_041303528.1 NZ_CP047972:199615-199914 [Kyrpidia spormannii]
MASVPEVLGLSETKRIMISVPSHLLQEVDGIAERENSNRSEVIRQAMRLYLEERKKERIRELMQRGYVEMAKINLYIASE
AFYAEEEAGSTLDRLVSGV

Download         Length: 300 bp

>AT148618 NZ_CP063804:c2208036-2207695 [Mycobacterium orygis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2K8N5K4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2K8N2G8

References