Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 3184408..3185093 Replicon chromosome
Accession NZ_CP047971
Organism Kyrpidia spormannii strain FAVT5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GWK40_RS15595 Protein ID WP_170099945.1
Coordinates 3184656..3185093 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GWK40_RS15590 Protein ID WP_232070152.1
Coordinates 3184408..3184659 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWK40_RS16790 3179922..3180011 + 90 WP_232070145.1 putative holin-like toxin -
GWK40_RS15555 3180383..3180808 - 426 WP_170099940.1 putative toxin-antitoxin system toxin component, PIN family -
GWK40_RS15560 3180805..3181071 - 267 Protein_3063 hypothetical protein -
GWK40_RS16795 3181008..3181253 + 246 WP_232070147.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
GWK40_RS16800 3181365..3181610 + 246 WP_232070148.1 PIN domain-containing protein -
GWK40_RS15575 3181596..3182096 - 501 WP_232070149.1 ImmA/IrrE family metallo-endopeptidase -
GWK40_RS16805 3182305..3182880 - 576 WP_232070150.1 zinc ribbon domain-containing protein -
GWK40_RS16810 3182835..3183614 - 780 WP_252346452.1 hypothetical protein -
GWK40_RS15585 3183797..3184174 - 378 WP_170099943.1 hypothetical protein -
GWK40_RS15590 3184408..3184659 + 252 WP_232070152.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GWK40_RS15595 3184656..3185093 + 438 WP_170099945.1 type II toxin-antitoxin system VapC family toxin Toxin
GWK40_RS16815 3185292..3185381 + 90 WP_232070153.1 putative holin-like toxin -
GWK40_RS15600 3186088..3186612 - 525 WP_170099946.1 Uma2 family endonuclease -
GWK40_RS15605 3186643..3186852 - 210 WP_197945651.1 hypothetical protein -
GWK40_RS15610 3186955..3187290 - 336 WP_170086642.1 PIN domain-containing protein -
GWK40_RS15615 3187283..3187807 - 525 WP_232059798.1 IS630 family transposase -
GWK40_RS15620 3187797..3188342 - 546 WP_170099947.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-64)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 16405.82 Da        Isoelectric Point: 7.1376

>T148617 WP_170099945.1 NZ_CP047971:3184656-3185093 [Kyrpidia spormannii]
VKYLLDTCVISELVKRAPAPAVLRWVENQDEENLYLSVLTLGELQRGVSKLLDRSRAEQLQAWLNDDLTHRFQRRILPVD
QKVAKAWGEISGDAARRGETLPVMDSLIAATAQVHGLVVVTRNVRDIERCRVPVTNPWPDTRADL

Download         Length: 438 bp

>T148617 NZ_CP063804:c2200231-2199812 [Mycobacterium orygis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9511.01 Da        Isoelectric Point: 10.3461

>AT148617 WP_232070152.1 NZ_CP047971:3184408-3184659 [Kyrpidia spormannii]
MDKTWQLQDAKNRLSELVHKAMRNGPQMITVRGKPAVVVVSVQEYERLVRPKTSLVEFFRSSPLVGVELDAERLRDHPRE
AGL

Download         Length: 252 bp

>AT148617 NZ_CP063804:c2200500-2200240 [Mycobacterium orygis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References