Detailed information of TA system TA148616

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 375875..376494
• Replicon: chromosome
• Accession: NZ_CP047971
• Organism: Kyrpidia spormannii strain FAVT5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GWK40_RS01985
• Protein ID: WP_170084800.1
• Coordinates: 376108..376494 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D5WW04
• Locus tag: GWK40_RS01980
• Protein ID: WP_013074928.1
• Coordinates: 375875..376111 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWK40_RS01970	372728..373930	+	1203	WP_269152992.1	transposase	-
GWK40_RS16370	374331..375044	+	714	WP_232070025.1	transposase	-
GWK40_RS16375	375113..375628	+	516	WP_232070026.1	transposase	-
GWK40_RS01980	375875..376111	+	237	WP_013074928.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GWK40_RS01985	376108..376494	+	387	WP_170084800.1	type II toxin-antitoxin system VapC family toxin	Toxin
GWK40_RS01990	376889..377899	-	1011	WP_170084801.1	GTP-binding protein	-
GWK40_RS16380	377913..378122	-	210	WP_232070027.1	hypothetical protein	-
GWK40_RS02000	378331..379215	-	885	WP_170084803.1	polysaccharide deacetylase	-
GWK40_RS02005	379240..380205	-	966	WP_170100012.1	asparaginase	-
GWK40_RS02010	380312..381460	-	1149	WP_170099039.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-44)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14884.15 Da
• Isoelectric Point: 4.7434

>T148616 WP_170084800.1 NZ_CP047971:376108-376494 [Kyrpidia spormannii]
MKTLLDTHVFLWWITDDGRMSKRARAIIQDTRNELYLSAASAWEIAIKAALGRIRVYEDLDRFMTQQMNENGIVDLPVEI
LHALGVYGLPDLHRDPFDRLLVAQAIQEGMPIITADEWIKRYDVETIW

Nucleotide

• Length: 387 bp

>T148616 NZ_CP063804:c2191108-2190812 [Mycobacterium orygis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8746.21 Da
• Isoelectric Point: 10.2014

>AT148616 WP_013074928.1 NZ_CP047971:375875-376111 [Kyrpidia spormannii]
VTKVVNVHEAKTHFSKLLARVEVGEEIVIAKAGKPLARLVPYRERPTKRVPGTAKSLIVVGEDFDDPLPESIQRLFER

Nucleotide

• Length: 237 bp

>AT148616 NZ_CP063804:c2191356-2191105 [Mycobacterium orygis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6F9E101