Detailed information of TA system TA148609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4815010..4815617
• Replicon: chromosome
• Accession: NZ_CP047965
• Organism: Enterobacter hormaechei strain 189

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2J0PXG2
• Locus tag: GUY47_RS23235
• Protein ID: WP_071788668.1
• Coordinates: 4815432..4815617 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A8H9RQ79
• Locus tag: GUY47_RS23230
• Protein ID: WP_032651934.1
• Coordinates: 4815010..4815417 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GUY47_RS23200	4810851..4811504	+	654	WP_023295601.1	3-keto-L-gulonate-6-phosphate decarboxylase UlaD	-
GUY47_RS23205	4811507..4812367	+	861	WP_017693794.1	L-ribulose-5-phosphate 3-epimerase	-
GUY47_RS23210	4812361..4813056	+	696	WP_017382588.1	L-ribulose-5-phosphate 4-epimerase	-
GUY47_RS23215	4813057..4813344	-	288	Protein_4537	helix-turn-helix domain-containing protein	-
GUY47_RS23220	4813351..4813728	+	378	Protein_4538	glycoside hydrolase family 127 protein	-
GUY47_RS23225	4813930..4815006	+	1077	WP_032651932.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
GUY47_RS23230	4815010..4815417	-	408	WP_032651934.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GUY47_RS23235	4815432..4815617	-	186	WP_071788668.1	type II toxin-antitoxin system HicA family toxin	Toxin
GUY47_RS23240	4815867..4817405	-	1539	WP_032651936.1	aldehyde dehydrogenase AldB	-
GUY47_RS23245	4817572..4818456	+	885	WP_032651938.1	ROK family protein	-
GUY47_RS23250	4818460..4820298	-	1839	WP_032651940.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6822.05 Da
• Isoelectric Point: 11.5191

>T148609 WP_071788668.1 NZ_CP047965:c4815617-4815432 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T148609 NZ_CP063804:c1583430-1583029 [Mycobacterium orygis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15110.90 Da
• Isoelectric Point: 4.3197

>AT148609 WP_032651934.1 NZ_CP047965:c4815417-4815010 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT148609 NZ_CP063804:c1583684-1583427 [Mycobacterium orygis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Structures

Toxin

• AlphaFold DB: A0A2J0PXG2