Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2500267..2501006 Replicon chromosome
Accession NZ_CP047965
Organism Enterobacter hormaechei strain 189

Toxin (Protein)


Gene name tacT Uniprot ID A0A7T9PDC6
Locus tag GUY47_RS12070 Protein ID WP_032653599.1
Coordinates 2500267..2500752 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag GUY47_RS12075 Protein ID WP_003857131.1
Coordinates 2500740..2501006 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY47_RS12040 2495765..2496379 + 615 WP_080337332.1 NUDIX hydrolase -
GUY47_RS12045 2496563..2497198 - 636 WP_015570517.1 DUF421 domain-containing protein -
GUY47_RS12050 2497208..2497654 - 447 WP_194229622.1 DUF3290 domain-containing protein -
GUY47_RS12055 2498083..2498411 - 329 Protein_2354 helix-turn-helix domain-containing protein -
GUY47_RS12060 2498666..2499631 + 966 WP_032648329.1 hypothetical protein -
GUY47_RS12065 2499647..2500216 + 570 WP_032648331.1 hypothetical protein -
GUY47_RS12070 2500267..2500752 - 486 WP_032653599.1 GNAT family N-acetyltransferase Toxin
GUY47_RS12075 2500740..2501006 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
GUY47_RS12080 2501070..2501999 - 930 WP_032653603.1 LysR family transcriptional regulator -
GUY47_RS12085 2502129..2503517 + 1389 WP_032653606.1 MFS transporter -
GUY47_RS12090 2503540..2504535 - 996 WP_017382342.1 DUF2891 domain-containing protein -
GUY47_RS12095 2504545..2505531 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17539.29 Da        Isoelectric Point: 10.3883

>T148598 WP_032653599.1 NZ_CP047965:c2500752-2500267 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGKAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T148598 NZ_CP063804:c756056-755673 [Mycobacterium orygis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT148598 WP_003857131.1 NZ_CP047965:c2501006-2500740 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT148598 NZ_CP063804:c756306-756151 [Mycobacterium orygis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9PDC6

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References