Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1923590..1924387 Replicon chromosome
Accession NZ_CP047965
Organism Enterobacter hormaechei strain 189

Toxin (Protein)


Gene name KacT Uniprot ID A0A222RDD1
Locus tag GUY47_RS09270 Protein ID WP_032647926.1
Coordinates 1923866..1924387 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5RT92
Locus tag GUY47_RS09265 Protein ID WP_001303459.1
Coordinates 1923590..1923859 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY47_RS09235 1919304..1920185 + 882 WP_032653182.1 hypothetical protein -
GUY47_RS09240 1920182..1920613 + 432 WP_050597034.1 hypothetical protein -
GUY47_RS09245 1921091..1921318 - 228 WP_006809324.1 YccJ family protein -
GUY47_RS09250 1921337..1921933 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
GUY47_RS09255 1922324..1922494 + 171 WP_001273664.1 general stress protein -
GUY47_RS09260 1922611..1923516 + 906 WP_032653183.1 DMT family transporter -
GUY47_RS09265 1923590..1923859 + 270 WP_001303459.1 DUF1778 domain-containing protein Antitoxin
GUY47_RS09270 1923866..1924387 + 522 WP_032647926.1 GNAT family N-acetyltransferase Toxin
GUY47_RS09275 1924446..1925768 - 1323 WP_032653185.1 pyrimidine utilization transport protein G -
GUY47_RS09280 1925790..1926281 - 492 WP_032653187.1 pyrimidine utilization flavin reductase protein F -
GUY47_RS09285 1926294..1926884 - 591 WP_017693662.1 malonic semialdehyde reductase -
GUY47_RS09290 1926894..1927694 - 801 WP_023296287.1 pyrimidine utilization protein D -
GUY47_RS09295 1927702..1928088 - 387 WP_015570870.1 pyrimidine utilization protein C -
GUY47_RS09300 1928100..1928789 - 690 WP_032653188.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19451.21 Da        Isoelectric Point: 7.4318

>T148597 WP_032647926.1 NZ_CP047965:1923866-1924387 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

>T148597 NZ_CP063804:720438-720845 [Mycobacterium orygis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10248.70 Da        Isoelectric Point: 5.8836

>AT148597 WP_001303459.1 NZ_CP047965:1923590-1923859 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT148597 NZ_CP063804:720181-720441 [Mycobacterium orygis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A222RDD1

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7BCZ2

References