Detailed information of TA system TA148593

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 177360..178079
• Replicon: chromosome
• Accession: NZ_CP047965
• Organism: Enterobacter hormaechei strain 189

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A144XIR2
• Locus tag: GUY47_RS00930
• Protein ID: WP_023305176.1
• Coordinates: 177360..177680 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: GUY47_RS00935
• Protein ID: WP_032620726.1
• Coordinates: 177714..178079 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GUY47_RS00890	172427..172870	+	444	WP_032652089.1	GNAT family N-acetyltransferase	-
GUY47_RS00895	172903..173424	-	522	WP_032652091.1	hypothetical protein	-
GUY47_RS00900	173487..173852	-	366	WP_071992867.1	DUF2778 domain-containing protein	-
GUY47_RS00905	173862..174347	-	486	WP_032652094.1	type VI secretion system tube protein Hcp	-
GUY47_RS00910	174611..175639	-	1029	WP_071992868.1	virulence RhuM family protein	-
GUY47_RS00915	175698..176039	-	342	WP_006812446.1	SymE family type I addiction module toxin	-
GUY47_RS00920	176176..176355	+	180	WP_071847017.1	toxin-antitoxin system HicB family antitoxin	-
GUY47_RS00925	176356..177195	-	840	WP_023302862.1	DUF2971 domain-containing protein	-
GUY47_RS00930	177360..177680	-	321	WP_023305176.1	TA system toxin CbtA family protein	Toxin
GUY47_RS00935	177714..178079	-	366	WP_032620726.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
GUY47_RS00940	178111..178332	-	222	WP_032620724.1	DUF987 domain-containing protein	-
GUY47_RS00945	178341..178811	-	471	WP_032620722.1	DNA repair protein RadC	-
GUY47_RS00950	178881..179702	-	822	WP_032620720.1	DUF945 domain-containing protein	-
GUY47_RS00955	180145..180336	-	192	WP_023305181.1	hypothetical protein	-
GUY47_RS00960	180395..181234	-	840	WP_050595703.1	hypothetical protein	-
GUY47_RS00965	181347..181781	-	435	WP_044488933.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12190.77 Da
• Isoelectric Point: 5.9559

>T148593 WP_023305176.1 NZ_CP047965:c177680-177360 [Enterobacter hormaechei]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS

Nucleotide

• Length: 321 bp

>T148593 NZ_CP063804:c699722-699309 [Mycobacterium orygis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13574.29 Da
• Isoelectric Point: 6.4673

>AT148593 WP_032620726.1 NZ_CP047965:c178079-177714 [Enterobacter hormaechei]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Nucleotide

• Length: 366 bp

>AT148593 NZ_CP063804:c699955-699719 [Mycobacterium orygis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Structures

Toxin

• AlphaFold DB: A0A144XIR2