148592

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 124563..125089 Replicon chromosome
Accession NZ_CP047965
Organism Enterobacter hormaechei strain 189

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag GUY47_RS00625 Protein ID WP_000323025.1
Coordinates 124802..125089 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag GUY47_RS00620 Protein ID WP_000534858.1
Coordinates 124563..124802 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY47_RS00605 120891..122129 + 1239 WP_000219087.1 IS110 family transposase -
GUY47_RS00610 122605..123177 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
GUY47_RS00615 123377..124300 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
GUY47_RS00620 124563..124802 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
GUY47_RS00625 124802..125089 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
GUY47_RS00630 125161..125319 + 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
GUY47_RS00635 125611..126315 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
GUY47_RS00640 126504..129511 + 3008 Protein_127 Tn3 family transposase -
GUY47_RS00645 129548..129718 - 171 Protein_128 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aph(3')-Ia - 108001..142651 34650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T148592 WP_000323025.1 NZ_CP047965:124802-125089 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T148592 NZ_CP063804:c697386-696994 [Mycobacterium orygis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT148592 WP_000534858.1 NZ_CP047965:124563-124802 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT148592 NZ_CP063804:c697640-697383 [Mycobacterium orygis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References