Detailed information of TA system TA148584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/AbrB(antitoxin)
• Location: 154219..154799
• Replicon: chromosome
• Accession: NZ_CP047961
• Organism: Synechococcus sp. PROS-9-1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SynPROS91_RS00735
• Protein ID: WP_186517553.1
• Coordinates: 154440..154799 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: SynPROS91_RS00730
• Protein ID: WP_186517551.1
• Coordinates: 154219..154443 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynPROS91_RS00710	149980..151689	-	1710	WP_186517545.1	hypothetical protein	-
SynPROS91_RS00715	151689..152834	-	1146	WP_186519266.1	polysaccharide biosynthesis/export family protein	-
SynPROS91_RS00720	153016..153786	+	771	WP_186517547.1	YdcF family protein	-
SynPROS91_RS00725	153990..154181	+	192	WP_186517549.1	hypothetical protein	-
SynPROS91_RS00730	154219..154443	+	225	WP_186517551.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SynPROS91_RS00735	154440..154799	+	360	WP_186517553.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SynPROS91_RS00740	154774..155169	-	396	WP_186517555.1	HEPN domain-containing protein	-
SynPROS91_RS00745	155166..155537	-	372	WP_186517557.1	nucleotidyltransferase domain-containing protein	-
SynPROS91_RS00750	155870..157027	+	1158	WP_186517559.1	GDP-mannose 4,6-dehydratase	-
SynPROS91_RS00755	157024..158013	+	990	WP_186517561.1	GDP-L-fucose synthase	-
SynPROS91_RS00760	158063..158221	+	159	WP_186517563.1	hypothetical protein	-
SynPROS91_RS00765	158228..159265	-	1038	Protein_150	UDP-glucose 4-epimerase GalE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-108)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13076.21 Da
• Isoelectric Point: 10.8992

>T148584 WP_186517553.1 NZ_CP047961:154440-154799 [Synechococcus sp. PROS-9-1]
VTAFPPFALVRVPFPFTERQAIKRRPALVLSKPAFQEQSGHLLLAMVTSARNSQWPTDWQIKDLQAAGLPQPCVVRFKLF
TLDQSLLIGSLGALSEADRRGVQSRLTEVAALSPADPKP

Nucleotide

• Length: 360 bp

>T148584 NZ_CP063785:c5903466-5903023 [Tolypothrix sp. PCC 7712]
ATGAAAAATATAGATACTGTAATTGTTACGACTCGGTTAGAATTCATTGCTCGTTATCTTGACAATCTGAAAAGATTCGA
GGCAATTACTTGGGATGATTATCTCAATAATATTGATAATCAATTAATTACAGAAAGACTGCTACAATTAATGGCTCAAG
CTGCGATAGATATTAACGATCATATCTTGTCAAAGCTAAATCCAGGAAATTCAAATACTAACTTTGAAGCTTTTATTGAG
CTTGGTAATTATGGTGTGATTACTCCCGAACTAGCAAAACAATTGGCACCATCATCTGGATTAAGAAATCGCCTAGTTCA
TGAATATGACGATATAGATCCGCAGCAAGTTTTTAGGGCAATTAGTTTCGCTTTACAGCAATATCCACTGTATGTCAGAC
AAGTCAACTCATATTTAATTTCTTTGAGTGAAGAGAATGGCTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8043.10 Da
• Isoelectric Point: 4.1409

>AT148584 WP_186517551.1 NZ_CP047961:154219-154443 [Synechococcus sp. PROS-9-1]
MDLATLTAKGQVTIPKGVRDALGLKRGDLVSWELEDESVRLRVVSPIDLGYLRGVQAGLTEWGSDEDEVAFADL

Nucleotide

• Length: 225 bp

>AT148584 NZ_CP063785:c5903915-5903463 [Tolypothrix sp. PCC 7712]
ATGCAAAACCACACTCCAACAATTACAGAACTTCAAGAACTTGCCTTACAACTTCCTGAAAAAATCCCTTACTTAAAAAT
GTTAGTGCTATTTGGTTCTAGAGCTACTGGTAATGCAAACGCAAAAAGTGACTGGGATTTTGCAGTTTTGTGTGATGAAG
AACAGCGTGAAGCTTACATAAAAAATAATATTTCAGGTTTGTTTGAATTACCTATGTTGATTGGCGAAGTATTAAAAATC
AATTCTGACAAAATCGACATTGTAGAACTTAATCACTGTTCTGAATTAATAGCACATTTTGTTGCTCGCGATGGCAAAGT
TTTGTATGAATCTGAAGCTGAAGAATTTGAAAAATTTAAACAAAAAGTATTACTAAGCAAATCAGAGCTTAAAAAAATTG
AACATATTAAACGACAAAACATTGAGCAGTTTCTCCAAAGATGGGGTGTATGA