Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 226621..227201 Replicon chromosome
Accession NZ_CP047959
Organism Synechococcus sp. SYN20

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SynSYN20_RS01125 Protein ID WP_186524395.1
Coordinates 226842..227201 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SynSYN20_RS01120 Protein ID WP_186524394.1
Coordinates 226621..226845 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynSYN20_RS01085 222302..223192 + 891 WP_186524388.1 NAD-dependent epimerase/dehydratase family protein -
SynSYN20_RS01090 223189..223809 + 621 WP_186524389.1 HAD hydrolase-like protein -
SynSYN20_RS01095 223875..224540 + 666 WP_186524390.1 class I SAM-dependent methyltransferase -
SynSYN20_RS01100 225173..225394 + 222 WP_186525360.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SynSYN20_RS01105 225394..225780 + 387 WP_186524391.1 PIN domain-containing protein -
SynSYN20_RS01110 225891..226235 - 345 WP_186524392.1 type II toxin-antitoxin system PemK/MazF family toxin -
SynSYN20_RS01115 226232..226459 - 228 WP_186524393.1 ribbon-helix-helix domain-containing protein -
SynSYN20_RS01120 226621..226845 + 225 WP_186524394.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SynSYN20_RS01125 226842..227201 + 360 WP_186524395.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SynSYN20_RS01130 227176..227571 - 396 WP_186525361.1 HEPN domain-containing protein -
SynSYN20_RS01135 227568..227939 - 372 WP_186524396.1 nucleotidyltransferase domain-containing protein -
SynSYN20_RS01140 228036..228368 + 333 Protein_225 VapC toxin family PIN domain ribonuclease -
SynSYN20_RS01145 228554..228847 + 294 WP_186524397.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
SynSYN20_RS01150 228844..229248 + 405 WP_186524398.1 type II toxin-antitoxin system VapC family toxin -
SynSYN20_RS01155 229497..231251 + 1755 WP_186524399.1 SLC13 family permease -
SynSYN20_RS01160 231248..231811 - 564 WP_186524400.1 ribosome maturation factor RimM -
SynSYN20_RS01165 231848..232030 + 183 WP_186524401.1 DUF3252 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-108)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13147.29 Da        Isoelectric Point: 10.7364

>T148582 WP_186524395.1 NZ_CP047959:226842-227201 [Synechococcus sp. SYN20]
VTAFPPFALVRVPFPFTERQVIKRRPALVLSKPAFQEHSGHLLLAMVTSARNSQWPTDWQIQDLQAAGLPQLCVVRFKLF
TLDQSLLIGSLGALSEADRRGVQSRLTEVAALSSVDPKP

Download         Length: 360 bp

>T148582 NZ_CP063785:4545248-4545610 [Tolypothrix sp. PCC 7712]
ATGCAGAGTGATAACACGGTTTCAATTCGATTTGCTGATGAGTTTGAGGAGAAACTCTACAGACTCTCAAAAAGATTTCG
CAATATTCGCTCTGATGTTCAACCCATTATCGAGCAATTACAACAAGGAAATATTGTAGGAGACAGGATTAGCGGTCTGG
GTGAGGAGTATATTGTTTACAAGGTGAGAGTTCGCAACAGTAATATTCAAAAAGGTAAAAGCGGTGGATACCGCCTCATC
TATCAACTTGAGTCACCCACAAGTATTTTGCTATTAACGATTTATTCCAAATCCGACCAAGAAGACATTGCTGCAAATGA
AATCCGCAATATTCTAGCTGATTTTGATAGTGAGGAAGGATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8043.10 Da        Isoelectric Point: 4.1409

>AT148582 WP_186524394.1 NZ_CP047959:226621-226845 [Synechococcus sp. SYN20]
MDLATLTAKGQVTIPKGVRDALGLKRGDLVSWELEDESVRLRVVSPLDLGYLRGVQAGLTEWGSDEDEVAFADL

Download         Length: 225 bp

>AT148582 NZ_CP063785:4545001-4545258 [Tolypothrix sp. PCC 7712]
ATGAAAGCGATCGAAGTGACTGGTAAGATTGACGCTCAAGGCAACCTGATTCTAGATGAGCCAATTCACGGAACAACCTA
TCCTCATCAGGTGCGGGTAATTGTATTGGTTCCAGAACCAGCAGAAACAGAAGAACTTGACCCAGATGATACACCAGTTG
AGGAAATTAAAGCTAGCTTGAGGAGAGCCTTAAAGCAAGCAAAAATGGGACAAACTCGACCAATTAGCGAGTTATGGGAC
AGAATTGATGCAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References