Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 221393..222081 Replicon chromosome
Accession NZ_CP047952
Organism Synechococcus sp. MEDNS5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SynMEDNS5_RS01055 Protein ID WP_186583926.1
Coordinates 221632..222081 (+) Length 150 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SynMEDNS5_RS01050 Protein ID WP_186583925.1
Coordinates 221393..221632 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynMEDNS5_RS01030 217077..218042 + 966 WP_186585767.1 glycosyltransferase family 4 protein -
SynMEDNS5_RS01035 218039..220012 + 1974 WP_186583922.1 polysaccharide biosynthesis protein -
SynMEDNS5_RS01040 220711..220896 - 186 WP_186583923.1 type II toxin-antitoxin system PemK/MazF family toxin -
SynMEDNS5_RS01045 220908..221024 - 117 WP_186583924.1 hypothetical protein -
SynMEDNS5_RS01050 221393..221632 + 240 WP_186583925.1 ribbon-helix-helix domain-containing protein Antitoxin
SynMEDNS5_RS01055 221632..222081 + 450 WP_186583926.1 PIN domain-containing protein Toxin
SynMEDNS5_RS01060 222128..222895 - 768 Protein_207 GDP-mannose 4,6-dehydratase -
SynMEDNS5_RS01065 222964..223857 + 894 WP_186583927.1 N-acetylmuramoyl-L-alanine amidase -
SynMEDNS5_RS01070 223878..224024 + 147 Protein_209 HEPN domain-containing protein -
SynMEDNS5_RS01075 224023..224244 + 222 Protein_210 nucleotidyltransferase domain-containing protein -
SynMEDNS5_RS01080 224250..224999 + 750 WP_186583928.1 YdcF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(6-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 150 a.a.        Molecular weight: 16035.37 Da        Isoelectric Point: 6.1357

>T148580 WP_186583926.1 NZ_CP047952:221632-222081 [Synechococcus sp. MEDNS5]
MDAPIALLDVNVLIALLDPQHVHHEPAHRWFQANASHGWATCPLTQNALLRILSNPRYPNSPGGPASVMPLLQGMLSHPG
HQFWPDLLSWSTDGELQAELLLHHGQITDTYLLALAVHQGGCLMSFDARLSTCAVPGGGGALCLIDSQV

Download         Length: 450 bp

>T148580 NZ_CP047952:221632-222081 [Synechococcus sp. MEDNS5]
ATGGACGCGCCGATTGCTTTGCTGGATGTGAACGTGTTGATCGCCTTGCTGGATCCCCAGCATGTGCATCACGAGCCTGC
CCATCGCTGGTTCCAGGCCAACGCCAGCCATGGCTGGGCGACATGTCCACTAACGCAGAATGCCCTGCTGCGCATCCTCA
GCAATCCTCGCTATCCCAACAGCCCCGGTGGTCCGGCTTCGGTGATGCCGTTGCTGCAGGGGATGCTTTCCCATCCAGGC
CACCAGTTCTGGCCTGACCTTCTCTCGTGGTCCACTGATGGCGAGCTGCAGGCTGAGCTGCTTCTTCATCACGGCCAGAT
CACCGACACCTACTTGCTGGCCCTGGCCGTGCACCAAGGGGGTTGCCTGATGAGCTTTGATGCACGATTGAGTACATGTG
CGGTGCCTGGGGGTGGCGGCGCGCTTTGCCTGATTGATTCCCAGGTGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8695.86 Da        Isoelectric Point: 4.7527

>AT148580 WP_186583925.1 NZ_CP047952:221393-221632 [Synechococcus sp. MEDNS5]
MRTTLQLDDDVLDAARVLARQQHLSVGEVISELARQALRRPAGLEEPPSERSGLPLLPIKSSGGVVDLNLVNQLRDEDR

Download         Length: 240 bp

>AT148580 NZ_CP047952:221393-221632 [Synechococcus sp. MEDNS5]
ATGCGTACCACGCTCCAGTTGGACGACGATGTGCTCGATGCTGCACGCGTTCTCGCCCGCCAGCAGCACCTCAGTGTTGG
TGAGGTGATCAGTGAATTGGCGCGCCAGGCGTTGCGCCGCCCTGCTGGGCTGGAGGAGCCGCCATCGGAGCGGTCCGGGT
TGCCTCTCTTGCCGATCAAGTCCTCAGGTGGCGTGGTTGACCTCAATCTGGTGAATCAGCTGCGTGATGAGGATCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References