Detailed information of TA system TA148580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 221393..222081
• Replicon: chromosome
• Accession: NZ_CP047952
• Organism: Synechococcus sp. MEDNS5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SynMEDNS5_RS01055
• Protein ID: WP_186583926.1
• Coordinates: 221632..222081 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SynMEDNS5_RS01050
• Protein ID: WP_186583925.1
• Coordinates: 221393..221632 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynMEDNS5_RS01030	217077..218042	+	966	WP_186585767.1	glycosyltransferase family 4 protein	-
SynMEDNS5_RS01035	218039..220012	+	1974	WP_186583922.1	polysaccharide biosynthesis protein	-
SynMEDNS5_RS01040	220711..220896	-	186	WP_186583923.1	type II toxin-antitoxin system PemK/MazF family toxin	-
SynMEDNS5_RS01045	220908..221024	-	117	WP_186583924.1	hypothetical protein	-
SynMEDNS5_RS01050	221393..221632	+	240	WP_186583925.1	ribbon-helix-helix domain-containing protein	Antitoxin
SynMEDNS5_RS01055	221632..222081	+	450	WP_186583926.1	PIN domain-containing protein	Toxin
SynMEDNS5_RS01060	222128..222895	-	768	Protein_207	GDP-mannose 4,6-dehydratase	-
SynMEDNS5_RS01065	222964..223857	+	894	WP_186583927.1	N-acetylmuramoyl-L-alanine amidase	-
SynMEDNS5_RS01070	223878..224024	+	147	Protein_209	HEPN domain-containing protein	-
SynMEDNS5_RS01075	224023..224244	+	222	Protein_210	nucleotidyltransferase domain-containing protein	-
SynMEDNS5_RS01080	224250..224999	+	750	WP_186583928.1	YdcF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (6-131)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16035.37 Da
• Isoelectric Point: 6.1357

>T148580 WP_186583926.1 NZ_CP047952:221632-222081 [Synechococcus sp. MEDNS5]
MDAPIALLDVNVLIALLDPQHVHHEPAHRWFQANASHGWATCPLTQNALLRILSNPRYPNSPGGPASVMPLLQGMLSHPG
HQFWPDLLSWSTDGELQAELLLHHGQITDTYLLALAVHQGGCLMSFDARLSTCAVPGGGGALCLIDSQV

Nucleotide

• Length: 450 bp

>T148580 NZ_CP047952:221632-222081 [Synechococcus sp. MEDNS5]
ATGGACGCGCCGATTGCTTTGCTGGATGTGAACGTGTTGATCGCCTTGCTGGATCCCCAGCATGTGCATCACGAGCCTGC
CCATCGCTGGTTCCAGGCCAACGCCAGCCATGGCTGGGCGACATGTCCACTAACGCAGAATGCCCTGCTGCGCATCCTCA
GCAATCCTCGCTATCCCAACAGCCCCGGTGGTCCGGCTTCGGTGATGCCGTTGCTGCAGGGGATGCTTTCCCATCCAGGC
CACCAGTTCTGGCCTGACCTTCTCTCGTGGTCCACTGATGGCGAGCTGCAGGCTGAGCTGCTTCTTCATCACGGCCAGAT
CACCGACACCTACTTGCTGGCCCTGGCCGTGCACCAAGGGGGTTGCCTGATGAGCTTTGATGCACGATTGAGTACATGTG
CGGTGCCTGGGGGTGGCGGCGCGCTTTGCCTGATTGATTCCCAGGTGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8695.86 Da
• Isoelectric Point: 4.7527

>AT148580 WP_186583925.1 NZ_CP047952:221393-221632 [Synechococcus sp. MEDNS5]
MRTTLQLDDDVLDAARVLARQQHLSVGEVISELARQALRRPAGLEEPPSERSGLPLLPIKSSGGVVDLNLVNQLRDEDR

Nucleotide

• Length: 240 bp

>AT148580 NZ_CP047952:221393-221632 [Synechococcus sp. MEDNS5]
ATGCGTACCACGCTCCAGTTGGACGACGATGTGCTCGATGCTGCACGCGTTCTCGCCCGCCAGCAGCACCTCAGTGTTGG
TGAGGTGATCAGTGAATTGGCGCGCCAGGCGTTGCGCCGCCCTGCTGGGCTGGAGGAGCCGCCATCGGAGCGGTCCGGGT
TGCCTCTCTTGCCGATCAAGTCCTCAGGTGGCGTGGTTGACCTCAATCTGGTGAATCAGCTGCGTGATGAGGATCGCTGA