Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-Phd
Location 1945072..1945583 Replicon chromosome
Accession NZ_CP047948
Organism Synechococcus sp. A15-127

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag SynA15127_RS10330 Protein ID WP_186484038.1
Coordinates 1945311..1945583 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag SynA15127_RS10325 Protein ID WP_186484037.1
Coordinates 1945072..1945314 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynA15127_RS10280 1940636..1941055 + 420 WP_186484030.1 DUF3119 family protein -
SynA15127_RS10285 1941076..1941330 + 255 WP_186484031.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
SynA15127_RS10290 1941327..1941719 + 393 WP_186484032.1 type II toxin-antitoxin system VapC family toxin -
SynA15127_RS10295 1941767..1942129 + 363 WP_186484033.1 nucleotidyltransferase domain-containing protein -
SynA15127_RS10300 1942126..1942518 + 393 WP_186484034.1 HEPN domain-containing protein -
SynA15127_RS10305 1942627..1943622 + 996 WP_186484035.1 DUF3086 domain-containing protein -
SynA15127_RS10310 1943627..1944016 - 390 WP_186484036.1 type II toxin-antitoxin system VapC family toxin -
SynA15127_RS10315 1944016..1944273 - 258 WP_186485693.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
SynA15127_RS10320 1944387..1944983 + 597 WP_186485694.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
SynA15127_RS10325 1945072..1945314 + 243 WP_186484037.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SynA15127_RS10330 1945311..1945583 + 273 WP_186484038.1 Txe/YoeB family addiction module toxin Toxin
SynA15127_RS10335 1945554..1945820 - 267 WP_186485695.1 hypothetical protein -
SynA15127_RS10340 1945949..1946683 - 735 WP_186485696.1 orotidine-5'-phosphate decarboxylase -
SynA15127_RS10345 1946819..1947757 + 939 WP_186484039.1 helix-turn-helix domain-containing protein -
SynA15127_RS10350 1947761..1949008 - 1248 WP_186484040.1 tyrosine--tRNA ligase -
SynA15127_RS10355 1949105..1949434 - 330 WP_043692536.1 DUF1825 family protein -
SynA15127_RS10360 1949571..1950272 + 702 WP_186485697.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10368.09 Da        Isoelectric Point: 10.4014

>T148576 WP_186484038.1 NZ_CP047948:1945311-1945583 [Synechococcus sp. A15-127]
VSWRVLFTRQAQKDARKLASASPALKAKAKQLIALLKADPYQQPPPYEALVGDLKGACSRRINIQHRLVYQVLDEERLVK
VLRLWSHYDE

Download         Length: 273 bp

>T148576 NZ_CP063780:c1964457-1964275 [Pseudomonas sp. OST1909]
GTGGATAGCCGCTATTTGATAGGTCACATCGTTGCAGACGGTTGGTATCTGGTGCGCATCAGGGGCAGTCATCATCACTT
CAAGCACCCGACAAAGCCCGGTCTGGTCACGATTCCTCATCCAAAAAAGGACCTGCTGGATAAAACCGCCAAGAGCATTT
TGAAACAGGCTCTGCTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8812.90 Da        Isoelectric Point: 4.3077

>AT148576 WP_186484037.1 NZ_CP047948:1945072-1945314 [Synechococcus sp. A15-127]
MASISVTEARKRLFALVDEVGESHTPIEIHGKRSNAVLVSEDDWRAIQETLYLTAIPGMRESILDGMASPTSELSEDPGW

Download         Length: 243 bp

>AT148576 NZ_CP063780:c1964252-1963842 [Pseudomonas sp. OST1909]
ATGCTTTATCCCATCGCAATTTCAACGGGCGACGAGGACCACGCCTGGGGCGTGGAAGTCCCGGATATTCCCGGGTGCTA
TTCCGCCGGCGATGACCTGGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAGGGGCACTTCGAGATCCTTGCAGAAG
ATGGCGCGCCGATCCCCTGCGCGCAGAAAGTCACCTTGCACGCCGCCAACCCACAGTACGCAGGCTGCACCTGGGCGGTG
GTAGACATCGACGTCACCAAGTACCTGGGCAAGGCGCAAAAACTCAACATCACCCTGCCGGGGTATCTGTTGAATCGCAT
CGATGACTATGTACTGAATCACCCGGAAGAAAAAAGCCGCTCGGGGTTTCTGGCGTCCGCGGCACTCAAGGTATTGCAAC
AGGATCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References