Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 284641..285221 Replicon chromosome
Accession NZ_CP047946
Organism Synechococcus sp. ROS8604

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SynROS8604_RS01420 Protein ID WP_186544880.1
Coordinates 284862..285221 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SynROS8604_RS01415 Protein ID WP_186544879.1
Coordinates 284641..284865 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynROS8604_RS01345 279850..280263 + 414 WP_186545737.1 nucleotidyltransferase substrate binding protein -
SynROS8604_RS01350 280263..280604 + 342 Protein_267 nucleotidyltransferase domain-containing protein -
SynROS8604_RS01355 280679..280846 + 168 WP_186544872.1 hypothetical protein -
SynROS8604_RS01360 280875..281144 + 270 WP_186545738.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SynROS8604_RS01365 281108..281447 + 340 Protein_270 PIN domain-containing protein -
SynROS8604_RS01370 281448..281775 - 328 Protein_271 PIN domain-containing protein -
SynROS8604_RS01375 281763..281927 - 165 WP_186546114.1 hypothetical protein -
SynROS8604_RS01380 282038..282202 + 165 WP_186544873.1 hypothetical protein -
SynROS8604_RS01385 282290..282553 + 264 WP_186544874.1 AbrB family transcriptional regulator -
SynROS8604_RS01390 282550..282942 + 393 WP_186544875.1 PIN domain-containing protein -
SynROS8604_RS01395 283000..283138 + 139 Protein_276 CopG family transcriptional regulator -
SynROS8604_RS01400 283224..283469 + 246 WP_186544876.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
SynROS8604_RS01405 283483..283920 + 438 WP_186544877.1 type II toxin-antitoxin system VapC family toxin -
SynROS8604_RS01410 284037..284318 + 282 WP_186544878.1 hypothetical protein -
SynROS8604_RS01415 284641..284865 + 225 WP_186544879.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SynROS8604_RS01420 284862..285221 + 360 WP_186544880.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SynROS8604_RS01425 285196..285591 - 396 WP_186544881.1 HEPN domain-containing protein -
SynROS8604_RS01430 285574..285816 + 243 WP_186545739.1 CopG family transcriptional regulator -
SynROS8604_RS01435 285816..286235 + 420 WP_186544882.1 PIN domain-containing protein -
SynROS8604_RS01440 286385..288139 + 1755 WP_186544883.1 SLC13 family permease -
SynROS8604_RS01445 288136..288699 - 564 WP_186544884.1 ribosome maturation factor RimM -
SynROS8604_RS01450 288736..288918 + 183 WP_011618181.1 DUF3252 domain-containing protein -
SynROS8604_RS01455 288923..289732 + 810 WP_186544885.1 ion transporter -
SynROS8604_RS01460 289764..290138 - 375 WP_186544886.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-108)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13134.31 Da        Isoelectric Point: 10.1914

>T148573 WP_186544880.1 NZ_CP047946:284862-285221 [Synechococcus sp. ROS8604]
VTAFPPFALVRVPFPFTERQVIKRRPALVLSKPAFQEQSGHLLLAMVTSARNSQWPTDWQIKDLQAAGLAQPCVIRFKVF
TLDQSLLMGSLGALSEVDQQGVQSRLLDVVALSHADPKP

Download         Length: 360 bp

>T148573 NZ_CP063779:c1479899-1479648 [Mongoliitalea daihaiensis]
TTGAAGGATTTAAGAGCAAAAGCGAAAATTTTGTTCAGGATCCAAAAACTTGAAATTGATGAACATTTCGGGGACTGTAA
ACCCGTAGGTGAAGGGATTCATGAATTGAGGATAGACTATGCTAAAGGATATAGAATCTACTTAAAGGAAAGAGAAGGGA
AAATCATTATTCTTCTAGTAGGTGGAGAAAAATCAACTCAACAAAAGGACATCGAAAGAGCAAAGGAAATTTGGAAAAGG
ATAAAAAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8057.12 Da        Isoelectric Point: 4.1409

>AT148573 WP_186544879.1 NZ_CP047946:284641-284865 [Synechococcus sp. ROS8604]
MDLATLTAKGQVTIPKGVRDALGLKRGDLVSWELEDESVRLRLVSPIDLGYLRGVQAGLTEWGSDEDEVAFADL

Download         Length: 225 bp

>AT148573 NZ_CP063779:c1479644-1479360 [Mongoliitalea daihaiensis]
ATGGAAACATCAAAATTTGATATAGCGGACTATTTGGACAGTAAGGAAATGATTGCTGAGTATTTAAATTCTGTTTTGGA
GGAAGGGGATAATGATGATGTAGTTGTTGCGCTTGGGCACATCGCAAAAGCAATTGGGATGTCCAAAATAGCGGAAGAAA
CAGGGATGAGTAGGCCAAGTTTGTATAAAGCCCTATCAACAGGATCGAAGCCCCAATTTGAAACAATAATGAAAGTATTA
AAAGCTGTTGGTGGTCAATTAAGAATAAATCCATTATCCACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References