Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 107856..108430 Replicon chromosome
Accession NZ_CP047945
Organism Synechococcus sp. PROS-7-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SynPROS71_RS00545 Protein ID WP_186595963.1
Coordinates 107856..108200 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SynPROS71_RS00550 Protein ID WP_186595964.1
Coordinates 108200..108430 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynPROS71_RS00510 103484..104551 + 1068 WP_186595951.1 NAD-dependent epimerase/dehydratase family protein -
SynPROS71_RS00515 104854..105198 + 345 WP_186595953.1 FkbM family methyltransferase -
SynPROS71_RS00520 105195..105593 + 399 WP_186595955.1 FkbM family methyltransferase -
SynPROS71_RS00525 106009..106233 + 225 WP_186595957.1 hypothetical protein -
SynPROS71_RS00535 106440..106895 - 456 WP_186595959.1 GNAT family N-acetyltransferase -
SynPROS71_RS00540 106923..107831 - 909 WP_186595961.1 N-acetylmuramoyl-L-alanine amidase -
SynPROS71_RS00545 107856..108200 - 345 WP_186595963.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SynPROS71_RS00550 108200..108430 - 231 WP_186595964.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SynPROS71_RS00555 108516..108863 + 348 WP_186595965.1 nucleotidyltransferase domain-containing protein -
SynPROS71_RS00560 108874..109377 + 504 WP_186595966.1 hypothetical protein -
SynPROS71_RS00565 109409..110350 + 942 WP_186595967.1 glucose-1-phosphate thymidylyltransferase RfbA -
SynPROS71_RS00570 110340..110957 + 618 WP_186595968.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
SynPROS71_RS00575 110954..111841 + 888 WP_186595969.1 dTDP-4-dehydrorhamnose reductase -
SynPROS71_RS00580 111834..113183 + 1350 WP_186595970.1 sugar transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(12-110)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12677.90 Da        Isoelectric Point: 9.9583

>T148572 WP_186595963.1 NZ_CP047945:c108200-107856 [Synechococcus sp. PROS-7-1]
MSEPYPTFSLVRVPFPFTDRTTMKRRPALVVSAPHFQSNSGHLVLAMVTSATKSSWPLDWSIQELEGTGLPKPCMVRLKL
FSLDERLILNGLGALAKSDRIGVAECLRQLLPLQ

Download         Length: 345 bp

>T148572 NZ_CP063779:c1479644-1479360 [Mongoliitalea daihaiensis]
ATGGAAACATCAAAATTTGATATAGCGGACTATTTGGACAGTAAGGAAATGATTGCTGAGTATTTAAATTCTGTTTTGGA
GGAAGGGGATAATGATGATGTAGTTGTTGCGCTTGGGCACATCGCAAAAGCAATTGGGATGTCCAAAATAGCGGAAGAAA
CAGGGATGAGTAGGCCAAGTTTGTATAAAGCCCTATCAACAGGATCGAAGCCCCAATTTGAAACAATAATGAAAGTATTA
AAAGCTGTTGGTGGTCAATTAAGAATAAATCCATTATCCACTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8212.24 Da        Isoelectric Point: 4.0785

>AT148572 WP_186595964.1 NZ_CP047945:c108430-108200 [Synechococcus sp. PROS-7-1]
MTIDIATVTAKGQVTVPKAIREALGLRQGDRLSWEVENGAARVKLVSPLDLDYLQGLEANLQDWASAADDEAFADL

Download         Length: 231 bp

>AT148572 NZ_CP063779:c1479899-1479648 [Mongoliitalea daihaiensis]
TTGAAGGATTTAAGAGCAAAAGCGAAAATTTTGTTCAGGATCCAAAAACTTGAAATTGATGAACATTTCGGGGACTGTAA
ACCCGTAGGTGAAGGGATTCATGAATTGAGGATAGACTATGCTAAAGGATATAGAATCTACTTAAAGGAAAGAGAAGGGA
AAATCATTATTCTTCTAGTAGGTGGAGAAAAATCAACTCAACAAAAGGACATCGAAAGAGCAAAGGAAATTTGGAAAAGG
ATAAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References