Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2383756..2384339 Replicon chromosome
Accession NZ_CP047943
Organism Synechococcus sp. RS9909

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SynRS9909_RS12675 Protein ID WP_007101339.1
Coordinates 2383756..2384010 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SynRS9909_RS12680 Protein ID WP_007101338.1
Coordinates 2384007..2384339 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynRS9909_RS12655 2379733..2380854 - 1122 WP_007101342.1 histidinol-phosphate aminotransferase family protein -
SynRS9909_RS12660 2380851..2381207 - 357 WP_007101341.1 DUF29 domain-containing protein -
SynRS9909_RS12665 2381255..2383072 - 1818 WP_007101340.1 arginine--tRNA ligase -
SynRS9909_RS12670 2383055..2383720 + 666 Protein_2480 phage integrase N-terminal SAM-like domain-containing protein -
SynRS9909_RS12675 2383756..2384010 + 255 WP_007101339.1 type II toxin-antitoxin system HicA family toxin Toxin
SynRS9909_RS12680 2384007..2384339 + 333 WP_007101338.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SynRS9909_RS12685 2384573..2385463 - 891 WP_007101337.1 carboxylating nicotinate-nucleotide diphosphorylase -
SynRS9909_RS12690 2385463..2385969 - 507 WP_050752477.1 hypothetical protein -
SynRS9909_RS12695 2386016..2387398 - 1383 WP_007101335.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
SynRS9909_RS12700 2387488..2387964 + 477 WP_116431387.1 DUF2062 domain-containing protein -
SynRS9909_RS12705 2388014..2388766 + 753 WP_007101333.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9519.86 Da        Isoelectric Point: 10.2915

>T148571 WP_007101339.1 NZ_CP047943:2383756-2384010 [Synechococcus sp. RS9909]
MKRKHQRTLELIFSRPVSGSLPWRDIEALFQELGGEVSERAGSRVAVVLFGEVRVFHRPHPSPDTDKGAVASIRKWFEEH
GVTP

Download         Length: 255 bp

>T148571 NZ_CP063779:825042-825302 [Mongoliitalea daihaiensis]
ATGAAACTAGCCTTCACCTTACACGCTTGGGAAGATTATAATTATTGGCAAAAAATAAATCCCAAAATGGTGAAGAAAAT
AAATGAGTTAATCAAAGTTATTCTTCGAACGCCCTTTGAAGGAATAGGGAAACCTGAACCTTTAAAACATGATTTAGCAG
GTTTTTGGTCTAGAAGAATTGATCAAGAACATAGAATTGTCTATCATGTAGATGGCCTTGAGATAACAATCATTTCATGT
AGATTTCATTACGATAGTTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12513.09 Da        Isoelectric Point: 4.9783

>AT148571 WP_007101338.1 NZ_CP047943:2384007-2384339 [Synechococcus sp. RS9909]
MNLMNVDGYHAKIEYDEEKDQFRGEILGVSGGADFYGSSPDELRREFKKSLEIFLEVCKEQGIEPRRQYSGKFNLRISPE
LHEKLAMTAEVQGKSLNTLAQEALQRSVTA

Download         Length: 333 bp

>AT148571 NZ_CP063779:824791-825042 [Mongoliitalea daihaiensis]
ATGATAGCAGCAAACTATTCCGAATTCAGAACAGGTTTAAAAAATTTTCTTGATCAAGTAGAACAGGAAAATGAGATTTT
GATTATCAAACGAAAATCAGGTAAAGGGGCTGTTGTGATCTCTCTTGAAGAGTATAATGCTATCATGGAAACTCTTCATT
TATTAAGCTCTAAGAAAAACGCCGATAGATTATATGAATCTATCGAACAAATGAAATCAGGCAAAATCTTACATCCTACC
TTAGAAAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References