Detailed information of TA system TA148571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2383756..2384339
• Replicon: chromosome
• Accession: NZ_CP047943
• Organism: Synechococcus sp. RS9909

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SynRS9909_RS12675
• Protein ID: WP_007101339.1
• Coordinates: 2383756..2384010 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SynRS9909_RS12680
• Protein ID: WP_007101338.1
• Coordinates: 2384007..2384339 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynRS9909_RS12655	2379733..2380854	-	1122	WP_007101342.1	histidinol-phosphate aminotransferase family protein	-
SynRS9909_RS12660	2380851..2381207	-	357	WP_007101341.1	DUF29 domain-containing protein	-
SynRS9909_RS12665	2381255..2383072	-	1818	WP_007101340.1	arginine--tRNA ligase	-
SynRS9909_RS12670	2383055..2383720	+	666	Protein_2480	phage integrase N-terminal SAM-like domain-containing protein	-
SynRS9909_RS12675	2383756..2384010	+	255	WP_007101339.1	type II toxin-antitoxin system HicA family toxin	Toxin
SynRS9909_RS12680	2384007..2384339	+	333	WP_007101338.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SynRS9909_RS12685	2384573..2385463	-	891	WP_007101337.1	carboxylating nicotinate-nucleotide diphosphorylase	-
SynRS9909_RS12690	2385463..2385969	-	507	WP_050752477.1	hypothetical protein	-
SynRS9909_RS12695	2386016..2387398	-	1383	WP_007101335.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
SynRS9909_RS12700	2387488..2387964	+	477	WP_116431387.1	DUF2062 domain-containing protein	-
SynRS9909_RS12705	2388014..2388766	+	753	WP_007101333.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9519.86 Da
• Isoelectric Point: 10.2915

>T148571 WP_007101339.1 NZ_CP047943:2383756-2384010 [Synechococcus sp. RS9909]
MKRKHQRTLELIFSRPVSGSLPWRDIEALFQELGGEVSERAGSRVAVVLFGEVRVFHRPHPSPDTDKGAVASIRKWFEEH
GVTP

Nucleotide

• Length: 255 bp

>T148571 NZ_CP063779:825042-825302 [Mongoliitalea daihaiensis]
ATGAAACTAGCCTTCACCTTACACGCTTGGGAAGATTATAATTATTGGCAAAAAATAAATCCCAAAATGGTGAAGAAAAT
AAATGAGTTAATCAAAGTTATTCTTCGAACGCCCTTTGAAGGAATAGGGAAACCTGAACCTTTAAAACATGATTTAGCAG
GTTTTTGGTCTAGAAGAATTGATCAAGAACATAGAATTGTCTATCATGTAGATGGCCTTGAGATAACAATCATTTCATGT
AGATTTCATTACGATAGTTAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12513.09 Da
• Isoelectric Point: 4.9783

>AT148571 WP_007101338.1 NZ_CP047943:2384007-2384339 [Synechococcus sp. RS9909]
MNLMNVDGYHAKIEYDEEKDQFRGEILGVSGGADFYGSSPDELRREFKKSLEIFLEVCKEQGIEPRRQYSGKFNLRISPE
LHEKLAMTAEVQGKSLNTLAQEALQRSVTA

Nucleotide

• Length: 333 bp

>AT148571 NZ_CP063779:824791-825042 [Mongoliitalea daihaiensis]
ATGATAGCAGCAAACTATTCCGAATTCAGAACAGGTTTAAAAAATTTTCTTGATCAAGTAGAACAGGAAAATGAGATTTT
GATTATCAAACGAAAATCAGGTAAAGGGGCTGTTGTGATCTCTCTTGAAGAGTATAATGCTATCATGGAAACTCTTCATT
TATTAAGCTCTAAGAAAAACGCCGATAGATTATATGAATCTATCGAACAAATGAAATCAGGCAAAATCTTACATCCTACC
TTAGAAAGCTGA