Detailed information of TA system TA148570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2219094..2219644
• Replicon: chromosome
• Accession: NZ_CP047943
• Organism: Synechococcus sp. RS9909

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SynRS9909_RS11805
• Protein ID: WP_007101510.1
• Coordinates: 2219094..2219453 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A3Z9K4
• Locus tag: SynRS9909_RS11810
• Protein ID: WP_007101509.1
• Coordinates: 2219450..2219644 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynRS9909_RS11775	2214245..2214622	+	378	WP_007101516.1	hypothetical protein	-
SynRS9909_RS11780	2214653..2215273	+	621	WP_007101515.1	phycobiliprotein lyase	-
SynRS9909_RS11785	2215388..2216149	+	762	WP_007101514.1	phycobilisome rod-core linker polypeptide	-
SynRS9909_RS11790	2216311..2217381	+	1071	WP_007101513.1	DUF4912 domain-containing protein	-
SynRS9909_RS11795	2217392..2217577	+	186	WP_007101512.1	hypothetical protein	-
SynRS9909_RS11800	2217667..2219061	+	1395	WP_050752621.1	DUF1669 domain-containing protein	-
SynRS9909_RS11805	2219094..2219453	-	360	WP_007101510.1	type II toxin-antitoxin system VapC family toxin	Toxin
SynRS9909_RS11810	2219450..2219644	-	195	WP_007101509.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
SynRS9909_RS11815	2219767..2220021	+	255	WP_007101508.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
SynRS9909_RS11820	2220005..2220406	+	402	WP_007101507.1	type II toxin-antitoxin system VapC family toxin	-
SynRS9909_RS11825	2220561..2220791	+	231	WP_007101505.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
SynRS9909_RS11830	2220779..2221177	+	399	WP_038001067.1	type II toxin-antitoxin system VapC family toxin	-
SynRS9909_RS11835	2221207..2221863	-	657	WP_083774519.1	response regulator transcription factor	-
SynRS9909_RS11840	2221898..2223022	-	1125	WP_186593726.1	histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-43)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 12948.19 Da
• Isoelectric Point: 6.6330

>T148570 WP_007101510.1 NZ_CP047943:c2219453-2219094 [Synechococcus sp. RS9909]
MILVDTSIWVDHLRSGMPQLMAALQENAVLIHPWVIGELACGNLRDRSRVLTLLQGLPAARVASPAEVLILIEQHELMGR
GIGFVDAQLLASAKLSHCTLWTQDRRLADLAHALGISPA

Nucleotide

• Length: 360 bp

>T148570 NZ_CP063779:824791-825042 [Mongoliitalea daihaiensis]
ATGATAGCAGCAAACTATTCCGAATTCAGAACAGGTTTAAAAAATTTTCTTGATCAAGTAGAACAGGAAAATGAGATTTT
GATTATCAAACGAAAATCAGGTAAAGGGGCTGTTGTGATCTCTCTTGAAGAGTATAATGCTATCATGGAAACTCTTCATT
TATTAAGCTCTAAGAAAAACGCCGATAGATTATATGAATCTATCGAACAAATGAAATCAGGCAAAATCTTACATCCTACC
TTAGAAAGCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7082.08 Da
• Isoelectric Point: 8.0619

>AT148570 WP_007101509.1 NZ_CP047943:c2219644-2219450 [Synechococcus sp. RS9909]
VRTTVNLDDQLLAQAQELCGHLERTHLLKEALQALVERESARRLAALAGSQPDLQPVPRRRSAA

Nucleotide

• Length: 195 bp

>AT148570 NZ_CP063779:825042-825302 [Mongoliitalea daihaiensis]
ATGAAACTAGCCTTCACCTTACACGCTTGGGAAGATTATAATTATTGGCAAAAAATAAATCCCAAAATGGTGAAGAAAAT
AAATGAGTTAATCAAAGTTATTCTTCGAACGCCCTTTGAAGGAATAGGGAAACCTGAACCTTTAAAACATGATTTAGCAG
GTTTTTGGTCTAGAAGAATTGATCAAGAACATAGAATTGTCTATCATGTAGATGGCCTTGAGATAACAATCATTTCATGT
AGATTTCATTACGATAGTTAA

Structures

Antitoxin

• AlphaFold DB: A3Z9K4