Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1180604..1181249 Replicon chromosome
Accession NZ_CP047943
Organism Synechococcus sp. RS9909

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SynRS9909_RS05725 Protein ID WP_186593807.1
Coordinates 1180827..1181249 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SynRS9909_RS05720 Protein ID WP_186593806.1
Coordinates 1180604..1180840 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynRS9909_RS05680 1175683..1176045 - 363 WP_007100002.1 UPF0175 family protein -
SynRS9909_RS05685 1176140..1176637 + 498 WP_186593799.1 hypothetical protein -
SynRS9909_RS05690 1176641..1177687 + 1047 WP_186593800.1 LysM peptidoglycan-binding domain-containing protein -
SynRS9909_RS05695 1177757..1178677 + 921 WP_186593801.1 hypothetical protein -
SynRS9909_RS05700 1178810..1179055 + 246 WP_186593802.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SynRS9909_RS05705 1179042..1179437 + 396 WP_186593803.1 type II toxin-antitoxin system VapC family toxin -
SynRS9909_RS05710 1179492..1179710 - 219 WP_186593804.1 hypothetical protein -
SynRS9909_RS05715 1180078..1180428 - 351 WP_186593805.1 hypothetical protein -
SynRS9909_RS05720 1180604..1180840 + 237 WP_186593806.1 DNA-binding protein Antitoxin
SynRS9909_RS05725 1180827..1181249 + 423 WP_186593807.1 type II toxin-antitoxin system VapC family toxin Toxin
SynRS9909_RS05730 1181293..1181559 - 267 WP_186593808.1 hypothetical protein -
SynRS9909_RS05735 1181579..1182178 - 600 WP_186593809.1 hypothetical protein -
SynRS9909_RS05740 1183044..1183361 + 318 WP_186593810.1 nucleotidyltransferase domain-containing protein -
SynRS9909_RS05745 1183358..1183732 + 375 WP_186593811.1 DUF86 domain-containing protein -
SynRS9909_RS05750 1183823..1184041 - 219 WP_186593812.1 DUF433 domain-containing protein -
SynRS9909_RS05755 1184257..1184556 - 300 WP_186593813.1 HigA family addiction module antidote protein -
SynRS9909_RS05760 1184565..1184843 - 279 WP_186593814.1 type II toxin-antitoxin system RelE/ParE family toxin -
SynRS9909_RS05765 1184936..1185874 + 939 WP_186593837.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15698.92 Da        Isoelectric Point: 5.1868

>T148567 WP_186593807.1 NZ_CP047943:1180827-1181249 [Synechococcus sp. RS9909]
MFLIDTNVISEARKGRRADPGVQAFWAETARDDTPLFLAAVTIGELRRGVELIRYRGDHPQAQLLEQWLLEVLETYGDRV
LDLDGDAAQIWGRLRVPNPHNAIDKQIAAIALLHNLTVVTRNTDDFAGCGVRLLNPFQVL

Download         Length: 423 bp

>T148567 NZ_CP063775:c22993-22835 [Escherichia coli O25b:H4-ST131]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8288.45 Da        Isoelectric Point: 5.0184

>AT148567 WP_186593806.1 NZ_CP047943:1180604-1180840 [Synechococcus sp. RS9909]
MADLLVRGVDDALVQALKKRAGAHGRSQEAELRAILSAALLSPPRRKLADLLAAMPDVGVDADFQRHDEPAAAADVFD

Download         Length: 237 bp

>AT148567 NZ_CP063775:c23077-23037 [Escherichia coli O25b:H4-ST131]
TTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References