Detailed information of TA system TA148566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 329632..331091
• Replicon: chromosome
• Accession: NZ_CP047943
• Organism: Synechococcus sp. RS9909

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: SynRS9909_RS01560
• Protein ID: WP_186593778.1
• Coordinates: 330237..331091 (+)
• Length: 285 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A3Z4Q4
• Locus tag: SynRS9909_RS01555
• Protein ID: WP_007100831.1
• Coordinates: 329632..330240 (+)
• Length: 203 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynRS9909_RS01540	324856..325959	+	1104	WP_007100834.1	hypothetical protein	-
SynRS9909_RS01545	325939..326238	-	300	WP_007100833.1	hypothetical protein	-
SynRS9909_RS01550	326529..329324	+	2796	WP_007100832.1	DUF3987 domain-containing protein	-
SynRS9909_RS01555	329632..330240	+	609	WP_007100831.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
SynRS9909_RS01560	330237..331091	+	855	WP_186593778.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
SynRS9909_RS01565	331683..332108	+	426	WP_162858345.1	hypothetical protein	-
SynRS9909_RS01570	332170..332799	+	630	WP_007100826.1	siphovirus Gp157 family protein	-
SynRS9909_RS01575	332886..333785	+	900	WP_007100825.1	RAD52 family DNA repair protein	-
SynRS9909_RS01580	334355..335113	+	759	WP_186593779.1	hypothetical protein	-
SynRS9909_RS01585	335436..335840	-	405	WP_186593780.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (35-259)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (12-56)

Sequences

Toxin

Protein

• Length: 285 a.a.
• Molecular weight: 32107.86 Da
• Isoelectric Point: 4.7047

>T148566 WP_186593778.1 NZ_CP047943:330237-331091 [Synechococcus sp. RS9909]
VKANRAASIRQRLLNRSRQEQETFDAVLNRFGRERLLYRIGISEYCDRFLLKGAMLFALWYDMPHRPTRDMDLLGFGPGE
LFVLERVFREIAQQRVDDGLAFSETVTAAEIRNEANYAGARVTLLATLEQARIPLQVDIGFGDPVTPEAEQIDYPVLLED
LPPPRLGAYPVYTVIAEKLQAIVSLGMVNSRLKDYFDLQVLLVREELDAQVLAEAVRRTFAVRSTPLPQQVPLGLSSEFG
EDPDKQAQWRAFLQRNELAEIPLPAVVSQIREGLVPVLFQAGEL

Nucleotide

• Length: 855 bp

>T148566 NZ_CP063774:c4982380-4982273 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 203 a.a.
• Molecular weight: 23086.18 Da
• Isoelectric Point: 11.4303

>AT148566 WP_007100831.1 NZ_CP047943:329632-330240 [Synechococcus sp. RS9909]
MLPVLDRKETALKLARSRGLLRAREAAAAGVDRSTLARLCDSGLLERLERGLYGLPAAAVREHVDLEIVAKRVPQAVFCL
LTALRLHGLGTQQPRRVWISLPRGVHRPTLQFPPLEVIHVQPELHRLQVESRRSGPIRLKIYGVEKTLVDCFRHRRRLGM
EPVLEALKDAISQRRLNVDELWRQAQAQRMQRVMTPYLEALL

Nucleotide

• Length: 609 bp

>AT148566 NZ_CP063774:4982428-4982494 [Escherichia coli O25b:H4-ST131]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Antitoxin

• AlphaFold DB: A3Z4Q4