Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 70821..71500 Replicon chromosome
Accession NZ_CP047943
Organism Synechococcus sp. RS9909

Toxin (Protein)


Gene name vapC Uniprot ID A3Z418
Locus tag SynRS9909_RS00370 Protein ID WP_007101063.1
Coordinates 70821..71252 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A3Z419
Locus tag SynRS9909_RS00375 Protein ID WP_007101062.1
Coordinates 71252..71500 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynRS9909_RS00350 66245..68254 + 2010 WP_007101067.1 ribonuclease J -
SynRS9909_RS00355 68283..68960 - 678 WP_186593855.1 hypothetical protein -
SynRS9909_RS00360 68917..69969 - 1053 WP_007101065.1 tRNA lysidine(34) synthetase TilS -
SynRS9909_RS00365 70020..70793 + 774 WP_007101064.1 DUF561 domain-containing protein -
SynRS9909_RS00370 70821..71252 - 432 WP_007101063.1 twitching motility protein PilT Toxin
SynRS9909_RS00375 71252..71500 - 249 WP_007101062.1 hypothetical protein Antitoxin
SynRS9909_RS00380 71612..71998 + 387 WP_007101061.1 phage holin family protein -
SynRS9909_RS00385 72021..74756 - 2736 WP_007101060.1 DNA mismatch repair protein MutS -
SynRS9909_RS00390 74809..75225 - 417 WP_007101059.1 PIN domain-containing protein -
SynRS9909_RS00395 75225..75455 - 231 WP_007101058.1 DUF2191 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15542.86 Da        Isoelectric Point: 7.8476

>T148563 WP_007101063.1 NZ_CP047943:c71252-70821 [Synechococcus sp. RS9909]
MRALLDINVIIALLDGQHSLHSTASQWLSHHAAAGWASCPISQNGVIRIMSQPSYPNAQPPAAIASRLAEACRHPSHQFW
GGALSLLDPRHLKWHCLLGPRQITDAYLLAVAVANDGCLVSFDRRIHHDLVPGATADQIVVVR

Download         Length: 432 bp

>T148563 NZ_CP063774:3919770-3920690 [Escherichia coli O25b:H4-ST131]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.00 Da        Isoelectric Point: 6.7133

>AT148563 WP_007101062.1 NZ_CP047943:c71500-71252 [Synechococcus sp. RS9909]
MRTTLDIDDDLLQAAKDLAKQQRMSAGQVVSTLLRQALTQAHHSPSEAAARPHPCGFRPFAGDPSRITNNADVEALRDAL
NL

Download         Length: 249 bp

>AT148563 NZ_CP063774:3919001-3919783 [Escherichia coli O25b:H4-ST131]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3Z418

Antitoxin

Source ID Structure
AlphaFold DB A3Z419

References