Detailed information of TA system TA148562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhoH-LOG/-
• Location: 1301837..1304148
• Replicon: chromosome
• Accession: NZ_CP047942
• Organism: Synechococcus sp. MVIR-18-1

Toxin (Protein)

• Gene name: PhoH
• Uniprot ID: -
• Locus tag: SynMVIR181_RS06835
• Protein ID: WP_186522798.1
• Coordinates: 1301837..1303240 (+)
• Length: 468 a.a.

Antitoxin (Protein)

• Gene name: LOG
• Uniprot ID: -
• Locus tag: SynMVIR181_RS06840
• Protein ID: WP_186588715.1
• Coordinates: 1303252..1304148 (+)
• Length: 299 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynMVIR181_RS06810	1297470..1298015	-	546	WP_186588712.1	ureidoglycolate lyase	-
SynMVIR181_RS06815	1298400..1298780	+	381	WP_186588713.1	hypothetical protein	-
SynMVIR181_RS06820	1299198..1300025	-	828	Protein_1327	ATPase	-
SynMVIR181_RS06825	1300186..1300410	+	225	WP_186525524.1	hypothetical protein	-
SynMVIR181_RS06830	1300382..1301656	-	1275	WP_186588714.1	cytochrome P450	-
SynMVIR181_RS06835	1301837..1303240	+	1404	WP_186522798.1	PhoH family protein	Toxin
SynMVIR181_RS06840	1303252..1304148	+	897	WP_186588715.1	LOG family protein	Antitoxin
SynMVIR181_RS06845	1304482..1305267	+	786	WP_186588716.1	ATP-binding cassette domain-containing protein	-
SynMVIR181_RS06850	1305305..1305871	-	567	WP_186588717.1	hypothetical protein	-
SynMVIR181_RS06855	1305924..1306067	-	144	WP_186522804.1	hypothetical protein	-
SynMVIR181_RS06860	1306187..1306624	+	438	Protein_1335	hypothetical protein	-
SynMVIR181_RS06865	1306827..1307060	-	234	WP_186588718.1	DUF3136 domain-containing protein	-
SynMVIR181_RS06870	1307590..1308570	+	981	WP_186522808.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-155)

Antitoxin

• LOG family (160-289)

Sequences

Toxin

Protein

• Length: 468 a.a.
• Molecular weight: 51086.29 Da
• Isoelectric Point: 5.9030

>T148562 WP_186522798.1 NZ_CP047942:1301837-1303240 [Synechococcus sp. MVIR-18-1]
MNKKVVVKKVVVLDTNVLLHDPEAPSSFGSDRIVLPIQVIEEIDRFKRDPSEKGRNSRRVARLLDGLRERGNLADGVPLT
PDGDGTLEVAFCRAETLAQLPPELRGGGGDNNILAVALEQMRAKGLSEAPEVVLITKDTNLRIKADAVGLAAQDYANDKV
AISDLYPGARGVKVSADLIDELRQNGRLSLKALPAEAVASLQPNEGVTLIDRDSSDHTFLARQHGDSGELEPLVWLKRAR
LGRLKPRNREQNFALDLLLDPSVELVTLVGKAGTGKTLLAIAAGLHQVADEHRYARLLVTRPPISLGKEIGFLPGTLDEK
LAPWMQPIVDNLDFLTGDAMSNEQKDDRRRHGGGPKSSWSDLREMGLLEVEAINYIRGRSIPHQFMVVDEAQNLTPHEVK
TIVTRVGEGTKIVFTGDPYQIDNPYVDAESNGLTWLAERLKGQTLVGHMTLTRGERSALAELAANML

Nucleotide

• Length: 1404 bp

>T148562 NZ_CP063774:3830547-3830699 [Escherichia coli O25b:H4-ST131]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 299 a.a.
• Molecular weight: 33046.60 Da
• Isoelectric Point: 5.6083

>AT148562 WP_186588715.1 NZ_CP047942:1303252-1304148 [Synechococcus sp. MVIR-18-1]
MVSNFLDSGLPSEDPTRVAHNLEQIIHSDNYRLAHQDLDLLNRSSMRGVRMLLEISKPELFLEEAGITSTIIVFGGARLQ
EKTAAEASLKEAIKELDANPDSAEWKRKVSRARKMVKLSSYYDAAREFAFLASHFGQSGPISGPSCSTHVIVTGGGPGIM
EAANRGAFDAGCRSIGLNIELPHEQNPNPYITPNLCFKFNYFALRKFHFVMRAVGAVLFPGGYGTLDELFELLTLRQVGT
QHAMPIVLFGKDYWSRLIDFEFMADSGLIDDKDLKLIQFADTATEAWDLIQNQTSNPG

Nucleotide

• Length: 897 bp

>AT148562 NZ_CP063774:c3830495-3830435 [Escherichia coli O25b:H4-ST131]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT