Detailed information of TA system TA148561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 229153..229811
• Replicon: chromosome
• Accession: NZ_CP047942
• Organism: Synechococcus sp. MVIR-18-1

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: -
• Locus tag: SynMVIR181_RS01155
• Protein ID: WP_186589703.1
• Coordinates: 229153..229560 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: SynMVIR181_RS01160
• Protein ID: WP_186589704.1
• Coordinates: 229557..229811 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynMVIR181_RS01095	224608..224790	+	183	WP_186589695.1	DUF3252 domain-containing protein	-
SynMVIR181_RS01100	224795..225604	+	810	WP_186589696.1	ion transporter	-
SynMVIR181_RS01105	225737..225910	-	174	WP_186589697.1	hypothetical protein	-
SynMVIR181_RS01110	225920..226684	-	765	WP_186589698.1	ribonuclease III	-
SynMVIR181_RS01125	227360..227833	-	474	WP_186590425.1	GNAT family N-acetyltransferase	-
SynMVIR181_RS01130	227830..228060	-	231	WP_186590426.1	DUF1778 domain-containing protein	-
SynMVIR181_RS01135	227978..228289	-	312	WP_186589699.1	hypothetical protein	-
SynMVIR181_RS01140	228373..228693	-	321	WP_186589700.1	hypothetical protein	-
SynMVIR181_RS01145	228680..228961	-	282	WP_186589701.1	hypothetical protein	-
SynMVIR181_RS01150	228990..229151	-	162	WP_186589702.1	hypothetical protein	-
SynMVIR181_RS01155	229153..229560	-	408	WP_186589703.1	type II toxin-antitoxin system VapC family toxin	Toxin
SynMVIR181_RS01160	229557..229811	-	255	WP_186589704.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SynMVIR181_RS01165	230178..230333	+	156	Protein_228	DUF4172 domain-containing protein	-
SynMVIR181_RS01170	230417..230800	-	384	WP_186589705.1	large conductance mechanosensitive channel protein MscL	-
SynMVIR181_RS01175	230948..231301	+	354	WP_186589706.1	hypothetical protein	-
SynMVIR181_RS01180	231338..231793	+	456	WP_006853778.1	hypothetical protein	-
SynMVIR181_RS01185	231880..234402	-	2523	WP_186589707.1	glycogen/starch/alpha-glucan phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• SpoVT-AbrB domain (9-27)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14910.03 Da
• Isoelectric Point: 5.5616

>T148561 WP_186589703.1 NZ_CP047942:c229560-229153 [Synechococcus sp. MVIR-18-1]
VIYLLDTNILIYLTKNRPPQVADRIDGISDEDSLAMSFVTWAELLRGAEGSQRREATLQQLEALTRLVHVLYPQGQGICE
HYAVQATALKRRATPIGANDLWIACHALSIGATLVSHNVGEFSRIEGLQLVDWAA

Nucleotide

• Length: 408 bp

>T148561 NZ_CP063774:3597596-3597880 [Escherichia coli O25b:H4-ST131]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9422.61 Da
• Isoelectric Point: 4.3855

>AT148561 WP_186589704.1 NZ_CP047942:c229811-229557 [Synechococcus sp. MVIR-18-1]
MEVLPSRVFMNGNSQAVRIPAEFRLSSDRVQISRTPEGDLLVHPCPSQRGQALMQALNGFDADFVDALEQQQAEKLPVQE
RDEL

Nucleotide

• Length: 255 bp

>AT148561 NZ_CP063774:3597360-3597593 [Escherichia coli O25b:H4-ST131]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG