Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 165805..166385 Replicon chromosome
Accession NZ_CP047942
Organism Synechococcus sp. MVIR-18-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SynMVIR181_RS00820 Protein ID WP_186589651.1
Coordinates 166026..166385 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SynMVIR181_RS00815 Protein ID WP_186589650.1
Coordinates 165805..166029 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynMVIR181_RS00785 162362..163498 + 1137 WP_186589646.1 hypothetical protein -
SynMVIR181_RS00790 163919..164689 + 771 WP_186589647.1 YdcF family protein -
SynMVIR181_RS00795 164676..164864 + 189 WP_186590419.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SynMVIR181_RS00800 164872..165201 - 330 WP_186590420.1 type II toxin-antitoxin system PemK/MazF family toxin -
SynMVIR181_RS00805 165213..165437 - 225 WP_186589648.1 ribbon-helix-helix domain-containing protein -
SynMVIR181_RS00810 165540..165782 + 243 WP_186589649.1 hypothetical protein -
SynMVIR181_RS00815 165805..166029 + 225 WP_186589650.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SynMVIR181_RS00820 166026..166385 + 360 WP_186589651.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SynMVIR181_RS00825 166360..166755 - 396 WP_186590421.1 HEPN domain-containing protein -
SynMVIR181_RS00830 166752..167123 - 372 WP_186589652.1 nucleotidyltransferase domain-containing protein -
SynMVIR181_RS00835 167303..167392 + 90 Protein_164 CopG family transcriptional regulator -
SynMVIR181_RS00840 167573..167986 + 414 WP_186589653.1 nucleotidyltransferase substrate binding protein -
SynMVIR181_RS00845 167986..168327 + 342 WP_186589654.1 nucleotidyltransferase domain-containing protein -
SynMVIR181_RS00850 168550..168783 + 234 WP_186590422.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SynMVIR181_RS00855 168783..169169 + 387 WP_186589655.1 PIN domain-containing protein -
SynMVIR181_RS00860 169170..169613 - 444 WP_186589656.1 PIN domain-containing protein -
SynMVIR181_RS00865 169610..169852 - 243 WP_186589657.1 hypothetical protein -
SynMVIR181_RS00870 170027..170464 - 438 WP_186589658.1 hypothetical protein -
SynMVIR181_RS00875 170470..170868 + 399 WP_186589659.1 PIN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-105)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13225.45 Da        Isoelectric Point: 11.0124

>T148560 WP_186589651.1 NZ_CP047942:166026-166385 [Synechococcus sp. MVIR-18-1]
VTAFPPFALVRVPFPFTERQAIKRRPALVLSKPAFQEQSGHLLLAMVTSARNSQWPTDWQIKDLQAAGLLQPCVVRFKVF
TLDKSLLIGSFGALSEADRRGVQSRWIEVVALSPADPKP

Download         Length: 360 bp

>T148560 NZ_CP063774:3487318-3487605 [Escherichia coli O25b:H4-ST131]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7985.06 Da        Isoelectric Point: 4.2264

>AT148560 WP_186589650.1 NZ_CP047942:165805-166029 [Synechococcus sp. MVIR-18-1]
MDLATLTAKGQVTIPKGVRDALGLKRGDLVSWELEGESVRLRVVSPIDLGYLRGVQAGLTEWGSDEDEVAFADL

Download         Length: 225 bp

>AT148560 NZ_CP063774:3487592-3487894 [Escherichia coli O25b:H4-ST131]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References