Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 992266..992876 Replicon chromosome
Accession NZ_CP047940
Organism Cyanobium sp. NS01

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CyaNS01_RS05145 Protein ID WP_186699396.1
Coordinates 992574..992876 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag CyaNS01_RS05140 Protein ID WP_186700293.1
Coordinates 992266..992577 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CyaNS01_RS05115 987952..989148 - 1197 WP_186699386.1 F420-0:Gamma-glutamyl ligase -
CyaNS01_RS05120 989229..990626 + 1398 WP_186699388.1 PhoH family protein -
CyaNS01_RS05125 990860..991036 + 177 WP_186699390.1 DUF2256 domain-containing protein -
CyaNS01_RS05130 991297..991707 - 411 WP_186699392.1 PIN domain-containing protein -
CyaNS01_RS05135 991710..991967 - 258 WP_186699394.1 ribbon-helix-helix protein, CopG family -
CyaNS01_RS05140 992266..992577 - 312 WP_186700293.1 putative addiction module antidote protein Antitoxin
CyaNS01_RS05145 992574..992876 - 303 WP_186699396.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CyaNS01_RS05150 993033..993956 - 924 WP_186699398.1 HNH endonuclease -
CyaNS01_RS05160 995576..996547 - 972 WP_186700295.1 integron integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 992123..996562 4439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-97)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11009.63 Da        Isoelectric Point: 8.4391

>T148558 WP_186699396.1 NZ_CP047940:c992876-992574 [Cyanobium sp. NS01]
MVEVRQTERFVQWLAGLRDLRARAKVQARIERLIGGNPGDVKPVGAGVSELRINYGPGYRVYYLQRGSALIILLAGGDKS
SQAKDIDEALLLADNLSEEI

Download         Length: 303 bp

>T148558 NZ_CP063774:3405458-3405835 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 10996.59 Da        Isoelectric Point: 5.1530

>AT148558 WP_186700293.1 NZ_CP047940:c992577-992266 [Cyanobium sp. NS01]
MMKVTTSPYDVAKHLRTQEEMAAYLEACIEEADGDVAFIAKALGDIARAQGMTKVAKDSGLSRESLYKALSGDRSPSFDT
ILKVVSALGLKLSATVRSEAEVA

Download         Length: 312 bp

>AT148558 NZ_CP063774:3405000-3405368 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References