Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 304520..305118 | Replicon | chromosome |
| Accession | NZ_CP047940 | ||
| Organism | Cyanobium sp. NS01 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | CyaNS01_RS01475 | Protein ID | WP_186698289.1 |
| Coordinates | 304520..304876 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | CyaNS01_RS01480 | Protein ID | WP_186698291.1 |
| Coordinates | 304876..305118 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CyaNS01_RS01430 | 299649..300860 | + | 1212 | WP_186700043.1 | PQQ-dependent sugar dehydrogenase | - |
| CyaNS01_RS01435 | 300864..301176 | - | 313 | Protein_282 | DUF962 domain-containing protein | - |
| CyaNS01_RS01440 | 301175..301723 | + | 549 | WP_186698275.1 | WbuC family cupin fold metalloprotein | - |
| CyaNS01_RS01445 | 301738..302034 | - | 297 | WP_186698277.1 | hypothetical protein | - |
| CyaNS01_RS01450 | 302103..302501 | - | 399 | WP_186698279.1 | cupin | - |
| CyaNS01_RS01455 | 302548..302907 | - | 360 | WP_186698281.1 | DUF1801 domain-containing protein | - |
| CyaNS01_RS01460 | 303105..303317 | - | 213 | WP_186698283.1 | type II toxin-antitoxin system HicA family toxin | - |
| CyaNS01_RS01465 | 303701..304054 | - | 354 | WP_186698285.1 | DUF86 domain-containing protein | - |
| CyaNS01_RS01470 | 304044..304352 | - | 309 | WP_186698287.1 | nucleotidyltransferase domain-containing protein | - |
| CyaNS01_RS01475 | 304520..304876 | - | 357 | WP_186698289.1 | endoribonuclease MazF | Toxin |
| CyaNS01_RS01480 | 304876..305118 | - | 243 | WP_186698291.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| CyaNS01_RS01485 | 305185..305388 | - | 204 | Protein_292 | phage integrase N-terminal SAM-like domain-containing protein | - |
| CyaNS01_RS01490 | 305450..306586 | + | 1137 | WP_186698293.1 | histidinol-phosphate aminotransferase family protein | - |
| CyaNS01_RS01495 | 306593..307357 | - | 765 | WP_186698295.1 | MBL fold metallo-hydrolase | - |
| CyaNS01_RS01500 | 307422..308015 | - | 594 | WP_186698297.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| CyaNS01_RS01505 | 308057..308485 | - | 429 | WP_186700045.1 | diacylglycerol kinase family protein | - |
| CyaNS01_RS01510 | 308554..309114 | - | 561 | WP_186700047.1 | rRNA maturation RNase YbeY | - |
| CyaNS01_RS01515 | 309118..309288 | - | 171 | WP_186698299.1 | DUF3285 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13170.40 Da Isoelectric Point: 8.4741
>T148557 WP_186698289.1 NZ_CP047940:c304876-304520 [Cyanobium sp. NS01]
MSTYVPDRGDLVWLEFTPQAGSEQRGRRPALVISPKAYNGKVGLALFCPITSKIKGYPFEVLLPDGYSVSGVVLSDQLKC
LDWRTRKAKFIERISLDVMEMVTARVLPLLEPDTPTTL
MSTYVPDRGDLVWLEFTPQAGSEQRGRRPALVISPKAYNGKVGLALFCPITSKIKGYPFEVLLPDGYSVSGVVLSDQLKC
LDWRTRKAKFIERISLDVMEMVTARVLPLLEPDTPTTL
Download Length: 357 bp
>T148557 NZ_CP063774:3305847-3306197 [Escherichia coli O25b:H4-ST131]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8460.62 Da Isoelectric Point: 5.6233
>AT148557 WP_186698291.1 NZ_CP047940:c305118-304876 [Cyanobium sp. NS01]
MQTRVQKWGNSLGVRIPRGLADEVGLGAGTEVSLTAKDGELVLRPSLPSRLRLVDLLADITPENIHASVHTGDAVGSEAF
MQTRVQKWGNSLGVRIPRGLADEVGLGAGTEVSLTAKDGELVLRPSLPSRLRLVDLLADITPENIHASVHTGDAVGSEAF
Download Length: 243 bp
>AT148557 NZ_CP063774:3305602-3305853 [Escherichia coli O25b:H4-ST131]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|