Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 304520..305118 Replicon chromosome
Accession NZ_CP047940
Organism Cyanobium sp. NS01

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CyaNS01_RS01475 Protein ID WP_186698289.1
Coordinates 304520..304876 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CyaNS01_RS01480 Protein ID WP_186698291.1
Coordinates 304876..305118 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CyaNS01_RS01430 299649..300860 + 1212 WP_186700043.1 PQQ-dependent sugar dehydrogenase -
CyaNS01_RS01435 300864..301176 - 313 Protein_282 DUF962 domain-containing protein -
CyaNS01_RS01440 301175..301723 + 549 WP_186698275.1 WbuC family cupin fold metalloprotein -
CyaNS01_RS01445 301738..302034 - 297 WP_186698277.1 hypothetical protein -
CyaNS01_RS01450 302103..302501 - 399 WP_186698279.1 cupin -
CyaNS01_RS01455 302548..302907 - 360 WP_186698281.1 DUF1801 domain-containing protein -
CyaNS01_RS01460 303105..303317 - 213 WP_186698283.1 type II toxin-antitoxin system HicA family toxin -
CyaNS01_RS01465 303701..304054 - 354 WP_186698285.1 DUF86 domain-containing protein -
CyaNS01_RS01470 304044..304352 - 309 WP_186698287.1 nucleotidyltransferase domain-containing protein -
CyaNS01_RS01475 304520..304876 - 357 WP_186698289.1 endoribonuclease MazF Toxin
CyaNS01_RS01480 304876..305118 - 243 WP_186698291.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CyaNS01_RS01485 305185..305388 - 204 Protein_292 phage integrase N-terminal SAM-like domain-containing protein -
CyaNS01_RS01490 305450..306586 + 1137 WP_186698293.1 histidinol-phosphate aminotransferase family protein -
CyaNS01_RS01495 306593..307357 - 765 WP_186698295.1 MBL fold metallo-hydrolase -
CyaNS01_RS01500 307422..308015 - 594 WP_186698297.1 aminodeoxychorismate/anthranilate synthase component II -
CyaNS01_RS01505 308057..308485 - 429 WP_186700045.1 diacylglycerol kinase family protein -
CyaNS01_RS01510 308554..309114 - 561 WP_186700047.1 rRNA maturation RNase YbeY -
CyaNS01_RS01515 309118..309288 - 171 WP_186698299.1 DUF3285 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-107)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13170.40 Da        Isoelectric Point: 8.4741

>T148557 WP_186698289.1 NZ_CP047940:c304876-304520 [Cyanobium sp. NS01]
MSTYVPDRGDLVWLEFTPQAGSEQRGRRPALVISPKAYNGKVGLALFCPITSKIKGYPFEVLLPDGYSVSGVVLSDQLKC
LDWRTRKAKFIERISLDVMEMVTARVLPLLEPDTPTTL

Download         Length: 357 bp

>T148557 NZ_CP063774:3305847-3306197 [Escherichia coli O25b:H4-ST131]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8460.62 Da        Isoelectric Point: 5.6233

>AT148557 WP_186698291.1 NZ_CP047940:c305118-304876 [Cyanobium sp. NS01]
MQTRVQKWGNSLGVRIPRGLADEVGLGAGTEVSLTAKDGELVLRPSLPSRLRLVDLLADITPENIHASVHTGDAVGSEAF

Download         Length: 243 bp

>AT148557 NZ_CP063774:3305602-3305853 [Escherichia coli O25b:H4-ST131]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References