Detailed information of TA system TA148556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1883500..1884031
• Replicon: chromosome
• Accession: NZ_CP047939
• Organism: Synechococcus sp. BMK-MC-1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SynBMKMC1_RS10620
• Protein ID: WP_186471704.1
• Coordinates: 1883762..1884031 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SynBMKMC1_RS10615
• Protein ID: WP_186471703.1
• Coordinates: 1883500..1883775 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynBMKMC1_RS10570	1879279..1879665	-	387	WP_186473429.1	hypothetical protein	-
SynBMKMC1_RS10575	1879823..1880095	-	273	WP_186471696.1	hypothetical protein	-
SynBMKMC1_RS10580	1880185..1880409	-	225	WP_186473430.1	DUF2811 domain-containing protein	-
SynBMKMC1_RS10585	1880730..1881113	-	384	WP_186471697.1	hypothetical protein	-
SynBMKMC1_RS10590	1881136..1881339	-	204	WP_186471698.1	hypothetical protein	-
SynBMKMC1_RS10595	1881338..1881823	+	486	WP_186471699.1	hypothetical protein	-
SynBMKMC1_RS10600	1882039..1882260	-	222	WP_186471700.1	hypothetical protein	-
SynBMKMC1_RS10605	1882427..1882654	-	228	WP_186471701.1	hypothetical protein	-
SynBMKMC1_RS10610	1882660..1883415	-	756	WP_186471702.1	C39 family peptidase	-
SynBMKMC1_RS10615	1883500..1883775	+	276	WP_186471703.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SynBMKMC1_RS10620	1883762..1884031	+	270	WP_186471704.1	Txe/YoeB family addiction module toxin	Toxin
SynBMKMC1_RS10625	1884095..1885030	+	936	WP_186471705.1	hypothetical protein	-
SynBMKMC1_RS10630	1885093..1885551	+	459	WP_186471706.1	hypothetical protein	-
SynBMKMC1_RS10635	1885577..1886458	+	882	WP_186471707.1	hypothetical protein	-
SynBMKMC1_RS10640	1886500..1887012	+	513	WP_186471708.1	hypothetical protein	-
SynBMKMC1_RS10645	1887042..1887329	-	288	WP_186473431.1	hypothetical protein	-
SynBMKMC1_RS10650	1887520..1887690	+	171	WP_186471709.1	hypothetical protein	-
SynBMKMC1_RS10655	1887763..1888107	-	345	WP_186471710.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10505.07 Da
• Isoelectric Point: 8.2643

>T148556 WP_186471704.1 NZ_CP047939:1883762-1884031 [Synechococcus sp. BMK-MC-1]
MPAADRLAWTAAAWEDYLYWQGQDRKQLRRINQLIQACLRDAFVGIGKPEPLRENLSGCWSRRIDDEHRLVYLLEGATLV
ILACRYHYR

Nucleotide

• Length: 270 bp

>T148556 NZ_CP063774:3202923-3203096 [Escherichia coli O25b:H4-ST131]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10077.36 Da
• Isoelectric Point: 5.0618

>AT148556 WP_186471703.1 NZ_CP047939:1883500-1883775 [Synechococcus sp. BMK-MC-1]
MQVVTFSEARERFKAVLDRVEADADVTLITRRNSQGAVVMSLDTYNSLMETVHLLRSPANAAHLQRSLEQAERGELLTHP
LIDVDSLNAGS

Nucleotide

• Length: 276 bp

>AT148556 NZ_CP063774:3202599-3202895 [Escherichia coli O25b:H4-ST131]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG