Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 70019..70698 Replicon chromosome
Accession NZ_CP047939
Organism Synechococcus sp. BMK-MC-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SynBMKMC1_RS00375 Protein ID WP_186472297.1
Coordinates 70019..70456 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SynBMKMC1_RS00380 Protein ID WP_186472298.1
Coordinates 70456..70698 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynBMKMC1_RS00345 65485..67509 + 2025 WP_186472293.1 ribonuclease J -
SynBMKMC1_RS00350 67512..68177 - 666 WP_186472294.1 hypothetical protein -
SynBMKMC1_RS00355 68183..69199 - 1017 WP_186472295.1 tRNA lysidine(34) synthetase TilS -
SynBMKMC1_RS00360 69275..69560 + 286 Protein_70 DUF561 domain-containing protein -
SynBMKMC1_RS00365 69534..69635 - 102 Protein_71 hypothetical protein -
SynBMKMC1_RS00370 69617..69784 - 168 WP_186472296.1 hypothetical protein -
SynBMKMC1_RS00375 70019..70456 - 438 WP_186472297.1 PIN domain-containing protein Toxin
SynBMKMC1_RS00380 70456..70698 - 243 WP_186472298.1 ribbon-helix-helix domain-containing protein Antitoxin
SynBMKMC1_RS00385 70823..71191 + 369 WP_186473258.1 Uma2 family endonuclease -
SynBMKMC1_RS00390 71182..71508 + 327 WP_186472299.1 hypothetical protein -
SynBMKMC1_RS00395 71492..71938 + 447 WP_186472300.1 hypothetical protein -
SynBMKMC1_RS00400 71997..72266 + 270 WP_186472301.1 integrase core domain-containing protein -
SynBMKMC1_RS00405 72933..73676 - 744 WP_186472302.1 SapC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15939.27 Da        Isoelectric Point: 6.9679

>T148552 WP_186472297.1 NZ_CP047939:c70456-70019 [Synechococcus sp. BMK-MC-1]
MRALLDINVLIALLDADHLMHAAAQRWLARELDAGWASCPVTQNGVLRILSQPAYPNQRPVAEVAERLAEACSHPSHRFW
SGGVSLISPASANWRQLLGHRQVTDAYLLAVAVAEGGRFVSFDQRISVDLVPQARPEQLVVIKSE

Download         Length: 438 bp

>T148552 NZ_CP063774:c2389167-2388640 [Escherichia coli O25b:H4-ST131]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8595.63 Da        Isoelectric Point: 6.2751

>AT148552 WP_186472298.1 NZ_CP047939:c70698-70456 [Synechococcus sp. BMK-MC-1]
MRTTLDIDDDVLRAAKELAQRERVSAGQVVSRLLRQAMTASGSPASVAPEGVAGFRPFSSSNPQVVTNEQVNAIRDREGL

Download         Length: 243 bp

>AT148552 NZ_CP063774:c2389440-2389174 [Escherichia coli O25b:H4-ST131]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References