Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2153361..2154010 Replicon chromosome
Accession NZ_CP047938
Organism Synechococcus sp. A15-44

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SynA1544_RS12185 Protein ID WP_186513947.1
Coordinates 2153361..2153753 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SynA1544_RS12190 Protein ID WP_186515575.1
Coordinates 2153753..2154010 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynA1544_RS12165 2149693..2150637 - 945 WP_186513943.1 hypothetical protein -
SynA1544_RS12170 2150642..2151136 + 495 WP_186513945.1 NUDIX hydrolase -
SynA1544_RS12175 2151360..2151827 + 468 Protein_2384 HipA domain-containing protein -
SynA1544_RS12180 2151917..2153173 - 1257 WP_186513946.1 glycosyltransferase WbuB -
SynA1544_RS12185 2153361..2153753 - 393 WP_186513947.1 type II toxin-antitoxin system VapC family toxin Toxin
SynA1544_RS12190 2153753..2154010 - 258 WP_186515575.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SynA1544_RS12195 2154072..2154758 - 687 Protein_2388 YdcF family protein -
SynA1544_RS12200 2154784..2156172 - 1389 WP_186515576.1 undecaprenyl-phosphate glucose phosphotransferase -
SynA1544_RS12205 2156226..2156399 - 174 WP_186513948.1 hypothetical protein -
SynA1544_RS12210 2156478..2156690 - 213 WP_186513949.1 hypothetical protein -
SynA1544_RS12215 2157072..2157428 - 357 Protein_2392 transposase -
SynA1544_RS12220 2157547..2158803 - 1257 WP_186513950.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

Antitoxin VapB-like

(16-84)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14084.94 Da        Isoelectric Point: 4.8138

>T148551 WP_186513947.1 NZ_CP047938:c2153753-2153361 [Synechococcus sp. A15-44]
MGIDHSAVLAILQNEPERPAFDAAIASADHRALSAASLVELSIVIEARYGSDGQGDLDLLLSTAQINIVNLDRQQAKIAR
AAFARYGKGRHRASLNLGDCFSYALAQWLEQPLLFKGDDFCNTDLQPACL

Download         Length: 393 bp

>T148551 NZ_CP063774:2077724-2078188 [Escherichia coli O25b:H4-ST131]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9602.12 Da        Isoelectric Point: 9.7388

>AT148551 WP_186515575.1 NZ_CP047938:c2154010-2153753 [Synechococcus sp. A15-44]
IKPVYTHRRRGSQHPNPEADRLAAQVACLAREIKMDVVILALKERLQRSLIYRLDQIALRCAARPSMDRRSADEICGYDA
SGLPS

Download         Length: 258 bp

>AT148551 NZ_CP063774:2077389-2077724 [Escherichia coli O25b:H4-ST131]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References