Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 2146509..2147080 Replicon chromosome
Accession NZ_CP047938
Organism Synechococcus sp. A15-44

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SynA1544_RS12140 Protein ID WP_186515574.1
Coordinates 2146509..2146853 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SynA1544_RS12145 Protein ID WP_186513937.1
Coordinates 2146856..2147080 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynA1544_RS12085 2141637..2142011 - 375 Protein_2366 N-acetylmuramoyl-L-alanine amidase -
SynA1544_RS12090 2142004..2142177 + 174 Protein_2367 cytochrome c biogenesis protein CcdA -
SynA1544_RS12095 2142182..2143480 + 1299 WP_186513928.1 cytochrome c biogenesis protein ResB -
SynA1544_RS12100 2143513..2143740 + 228 WP_186513929.1 ribbon-helix-helix domain-containing protein -
SynA1544_RS12105 2143737..2144081 + 345 WP_186513930.1 type II toxin-antitoxin system PemK/MazF family toxin -
SynA1544_RS12110 2144212..2144538 + 327 Protein_2371 nucleotidyltransferase domain-containing protein -
SynA1544_RS12115 2144525..2144908 + 384 WP_186513931.1 HEPN domain-containing protein -
SynA1544_RS12120 2144905..2145213 + 309 WP_186513932.1 nucleotidyltransferase domain-containing protein -
SynA1544_RS12125 2145210..2145611 + 402 WP_186513933.1 HEPN domain-containing protein -
SynA1544_RS12130 2145627..2145974 + 348 WP_186513934.1 nucleotidyltransferase domain-containing protein -
SynA1544_RS12135 2145998..2146621 + 624 WP_186513935.1 hypothetical protein -
SynA1544_RS12140 2146509..2146853 - 345 WP_186515574.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SynA1544_RS12145 2146856..2147080 - 225 WP_186513937.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SynA1544_RS12150 2147138..2147539 - 402 WP_186513939.1 preQ(1) synthase -
SynA1544_RS12155 2147650..2147988 + 339 WP_186513941.1 P-II family nitrogen regulator -
SynA1544_RS12160 2148024..2149648 - 1625 Protein_2381 polysaccharide biosynthesis protein -
SynA1544_RS12165 2149693..2150637 - 945 WP_186513943.1 hypothetical protein -
SynA1544_RS12170 2150642..2151136 + 495 WP_186513945.1 NUDIX hydrolase -
SynA1544_RS12175 2151360..2151827 + 468 Protein_2384 HipA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-106)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12701.71 Da        Isoelectric Point: 10.9383

>T148550 WP_186515574.1 NZ_CP047938:c2146853-2146509 [Synechococcus sp. A15-44]
IAQSFELVRVPFPFTDRQATKRRPALVISRPMFQQHSGHLLLAMVTSAKHSQWPSDWPIEDLQAAGLPQACVVRFKLFSL
DQSLLLGSLGQLSTRDQRGVLSRLDAVAALRPPD

Download         Length: 345 bp

>T148550 NZ_CP063774:c2036408-2036094 [Escherichia coli O25b:H4-ST131]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8020.20 Da        Isoelectric Point: 4.7513

>AT148550 WP_186513937.1 NZ_CP047938:c2147080-2146856 [Synechococcus sp. A15-44]
VELATLTAKGQVTIPKAVREALGMKRGDLVSWELDKESVRLRVVPAIDHVYLKGVQAGLTEWGSEADEEAFAGL

Download         Length: 225 bp

>AT148550 NZ_CP063774:c2036097-2035681 [Escherichia coli O25b:H4-ST131]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References