Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1994197..1994798 Replicon chromosome
Accession NZ_CP047938
Organism Synechococcus sp. A15-44

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SynA1544_RS11155 Protein ID WP_186513646.1
Coordinates 1994197..1994556 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SynA1544_RS11160 Protein ID WP_186513650.1
Coordinates 1994553..1994798 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynA1544_RS11145 1991270..1991695 + 426 WP_186513642.1 tellurite resistance TerB family protein -
SynA1544_RS11150 1991989..1994019 + 2031 WP_186513644.1 transglutaminase family protein -
SynA1544_RS11155 1994197..1994556 - 360 WP_186513646.1 endoribonuclease MazF Toxin
SynA1544_RS11160 1994553..1994798 - 246 WP_186513650.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SynA1544_RS11165 1995001..1995313 - 313 Protein_2184 putative addiction module antidote protein -
SynA1544_RS11170 1995313..1995623 - 311 Protein_2185 type II toxin-antitoxin system RelE/ParE family toxin -
SynA1544_RS11175 1995696..1995872 - 177 WP_186513652.1 hypothetical protein -
SynA1544_RS11180 1995971..1996624 + 654 WP_186513654.1 hypothetical protein -
SynA1544_RS11185 1996691..1997191 + 501 WP_186513661.1 hypothetical protein -
SynA1544_RS11190 1997248..1999422 - 2175 WP_186513662.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-108)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12687.85 Da        Isoelectric Point: 9.1201

>T148549 WP_186513646.1 NZ_CP047938:c1994556-1994197 [Synechococcus sp. A15-44]
MTAAYVPGRGDLVWLEFTPQTGSEQAGRRPALVISPKAYNAKVGLALFCPVTSRVKGYPFEVALPEGSGVVGVVLADQLK
SLDWRARKAKLIECASPDVLAMVTARILPLLVPDNPSTP

Download         Length: 360 bp

>T148549 NZ_CP063774:1856321-1856698 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8428.53 Da        Isoelectric Point: 4.3178

>AT148549 WP_186513650.1 NZ_CP047938:c1994798-1994553 [Synechococcus sp. A15-44]
MQTRVQKWGNSLGVRIPRGLAEEVGLGAGSEVSLSTKNGELVVTPSIPARISLDDLLAEVSEENLHSSIDTGVAVGAEIV
C

Download         Length: 246 bp

>AT148549 NZ_CP063774:1855864-1856232 [Escherichia coli O25b:H4-ST131]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References