Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1407930..1408549 Replicon chromosome
Accession NZ_CP047938
Organism Synechococcus sp. A15-44

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SynA1544_RS08010 Protein ID WP_186512877.1
Coordinates 1407930..1408322 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SynA1544_RS08015 Protein ID WP_186512879.1
Coordinates 1408319..1408549 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynA1544_RS07975 1403695..1403949 + 255 WP_186512867.1 hypothetical protein -
SynA1544_RS07980 1403977..1404702 - 726 WP_186512869.1 YcgJ family protein -
SynA1544_RS07985 1404760..1405527 + 768 WP_186512871.1 class I SAM-dependent methyltransferase -
SynA1544_RS07990 1405497..1406435 - 939 Protein_1554 glycerate dehydrogenase -
SynA1544_RS07995 1406508..1406876 - 369 WP_186512873.1 hypothetical protein -
SynA1544_RS08000 1406975..1407430 + 456 WP_186512875.1 hypothetical protein -
SynA1544_RS08005 1407427..1407884 + 458 Protein_1557 HD domain-containing protein -
SynA1544_RS08010 1407930..1408322 - 393 WP_186512877.1 type II toxin-antitoxin system VapC family toxin Toxin
SynA1544_RS08015 1408319..1408549 - 231 WP_186512879.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SynA1544_RS08020 1408761..1412261 + 3501 WP_186512881.1 TM0106 family RecB-like putative nuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14976.40 Da        Isoelectric Point: 6.2278

>T148546 WP_186512877.1 NZ_CP047938:c1408322-1407930 [Synechococcus sp. A15-44]
MTRLLLDTHLVLWWLNGDSRLPKAVVERVQMPEAEVFVSQASLWEMAIKVSLGRLQVDLAELERQVPLQGFRWLSIRQAH
LLAVAELDCDGEHRDPFDRLLVCQSRTEPMLLLTVDRQLSRYGTTVQRVG

Download         Length: 393 bp

>T148546 NZ_CP063774:c788318-788064 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8265.51 Da        Isoelectric Point: 4.3806

>AT148546 WP_186512879.1 NZ_CP047938:c1408549-1408319 [Synechococcus sp. A15-44]
MKPVNIHQAKTQLSQLLQVVEQGEEVVIARAGVPIARLVSWQDQDRAVSAPGAMRGLIQMADDFDAPLDALFEALP

Download         Length: 231 bp

>AT148546 NZ_CP063774:c788566-788315 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References