Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1198738..1199348 Replicon chromosome
Accession NZ_CP047932
Organism Synechococcus sp. WH 8101

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag SynRCC2555_RS06315 Protein ID WP_130129025.1
Coordinates 1198738..1199040 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag SynRCC2555_RS06320 Protein ID WP_130129026.1
Coordinates 1199040..1199348 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynRCC2555_RS06295 1194213..1195844 - 1632 WP_130129021.1 hypothetical protein -
SynRCC2555_RS06300 1195844..1196890 - 1047 WP_130129022.1 hypothetical protein -
SynRCC2555_RS06305 1197126..1197866 + 741 WP_130129023.1 hypothetical protein -
SynRCC2555_RS06310 1197902..1198072 - 171 WP_165380942.1 hypothetical protein -
SynRCC2555_RS06315 1198738..1199040 + 303 WP_130129025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SynRCC2555_RS06320 1199040..1199348 + 309 WP_130129026.1 putative addiction module antidote protein Antitoxin
SynRCC2555_RS06325 1199444..1200193 + 750 WP_130129027.1 GNAT family N-acetyltransferase -
SynRCC2555_RS06330 1200664..1200846 - 183 WP_130129028.1 hypothetical protein -
SynRCC2555_RS06335 1200846..1201130 - 285 WP_130129029.1 hypothetical protein -
SynRCC2555_RS06340 1201722..1201934 + 213 WP_130129030.1 hypothetical protein -
SynRCC2555_RS06345 1201950..1202270 - 321 WP_130129031.1 hypothetical protein -
SynRCC2555_RS06350 1202304..1203047 - 744 WP_130129032.1 fatty acid desaturase -
SynRCC2555_RS06355 1203037..1204008 - 972 WP_130129033.1 orange carotenoid-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11207.76 Da        Isoelectric Point: 10.4145

>T148544 WP_130129025.1 NZ_CP047932:1198738-1199040 [Synechococcus sp. WH 8101]
VVEVRQTERFAQWLGDLRDLRARARVQARIERLIGGNPGDVKPIGSGVSELRINYGPGYRVYFQQKGSTLIILLAGGDKS
SQSRDIEEALLLARQITENR

Download         Length: 303 bp

>T148544 NZ_CP063774:c516659-516557 [Escherichia coli O25b:H4-ST131]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10876.47 Da        Isoelectric Point: 4.6181

>AT148544 WP_130129026.1 NZ_CP047932:1199040-1199348 [Synechococcus sp. WH 8101]
MKIKTLPYDVAETLRTPDEMAAYLEACIEDADGDAAFIAKALGDIARAQGMTQIARQTGLSRESLYKALSGDRSPSFDTV
LKVISALGLKLSAGVQEKAEVV

Download         Length: 309 bp

>AT148544 NZ_CP063774:516519-516787 [Escherichia coli O25b:H4-ST131]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References