Detailed information of TA system TA148537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3056760..3057459
• Replicon: chromosome
• Accession: NZ_CP047929
• Organism: Proteus mirabilis strain ChSC1905

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: GV833_RS14275
• Protein ID: WP_004249093.1
• Coordinates: 3057073..3057459 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: GV833_RS14270
• Protein ID: WP_004246828.1
• Coordinates: 3056760..3057080 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV833_RS14240	3051891..3052166	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
GV833_RS14245	3052221..3052844	-	624	WP_004246821.1	guanylate kinase	-
GV833_RS14250	3053145..3053762	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
GV833_RS14255	3053899..3055185	+	1287	WP_087741020.1	DUF3748 domain-containing protein	-
GV833_RS14260	3055400..3056284	+	885	WP_004249091.1	endonuclease/exonuclease/phosphatase family protein	-
GV833_RS14265	3056277..3056711	+	435	WP_004246827.1	hypothetical protein	-
GV833_RS14270	3056760..3057080	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
GV833_RS14275	3057073..3057459	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GV833_RS14280	3057621..3059693	-	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
GV833_RS14285	3059703..3060608	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
GV833_RS14290	3060859..3061440	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T148537 WP_004249093.1 NZ_CP047929:c3057459-3057073 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T148537 NZ_CP063773:2370910-2371404 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGATTTCCGCCCCTGAGCCACTCCGCGCCGAACATGTACTATCTTCATTCTGTTGCGGCGTGGAGTCCATGGATAACTG
GCTAAAACAACGGGCGATGAAAAATCAGGTCACTGGAGCATCACGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGTGCCGTGGCAACGAATGCCGCTCCTGGACGTTTTCGTCGCAATATGCCCGATCCTATT
CCGGTCGTGGTACTGGGTCGTCTGGCGGTGGATAAATCATTGCATGGTCAGGGCGTTGGCCGGGCTTTGGTACGTGATGC
TGGGCTAAGAGTGATTCAAGTGGCGGATACCATCGGTATTCGCGGGATGTTGGTTCATGCGCTGTCTGATGAAGCACGGG
AATTCTACCTGCGGGTGGGGTTTGAGCCTTCACCGATTGATCCGATGATGTTGATGGTAACGTTGGGGGATTTGGTGGGT
AGTTTGTCAATTTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT148537 WP_004246828.1 NZ_CP047929:c3057080-3056760 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT148537 NZ_CP063773:2370620-2370913 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGCCAGTGACGAACAGCGTTTCTGTTAAACGTGAAACATTGAATTTGCGCATCAAGCCCGCCGAACGCGATCTGATTGA
TCGTGCAGCAAAGGCTAGGGGAAAAAATCGCACTGATTTTGTCCTTGAGGCTGCGCGTGCCGCCGCAGAGGAAGTGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTACTCGCTTGGATCAGGCTCCTGCACCAAAT
GCCGCGCTGCGAAAAACCATGCAAACGCCAGCACCGTGGGAACAGAAAAAATGA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97