Detailed information of TA system TA148536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2757225..2758796
• Replicon: chromosome
• Accession: NZ_CP047929
• Organism: Proteus mirabilis strain ChSC1905

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4F0T8
• Locus tag: GV833_RS12950
• Protein ID: WP_012368637.1
• Coordinates: 2757483..2758796 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: GV833_RS12945
• Protein ID: WP_004249771.1
• Coordinates: 2757225..2757482 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV833_RS12920	2753187..2753330	+	144	WP_004246509.1	50S ribosomal protein L34	-
GV833_RS12925	2753348..2753707	+	360	WP_004246510.1	ribonuclease P protein component	-
GV833_RS12930	2753671..2753931	+	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
GV833_RS12935	2753934..2755574	+	1641	WP_004246512.1	membrane protein insertase YidC	-
GV833_RS12940	2755712..2757076	+	1365	WP_012368638.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
GV833_RS12945	2757225..2757482	+	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
GV833_RS12950	2757483..2758796	+	1314	WP_012368637.1	type II toxin-antitoxin system HipA family toxin	Toxin
GV833_RS12955	2759200..2759664	+	465	WP_012368636.1	DUF1097 domain-containing protein	-
GV833_RS12960	2759849..2760778	+	930	WP_004246518.1	metallophosphoesterase	-
GV833_RS12965	2760810..2762771	+	1962	WP_172767808.1	hypothetical protein	-
GV833_RS12970	2762825..2763628	-	804	WP_104836842.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49670.78 Da
• Isoelectric Point: 6.5023

>T148536 WP_012368637.1 NZ_CP047929:2757483-2758796 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T148536 NZ_CP063773:2144543-2144956 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
GTGGCCCAGTGGCAATGTGATCTTCGCGTTTCCTGGCGTATGCAACTGCTTTCATTGATTGTGCATGGCCTATTAGTATT
GCTCATTCTTCTGGCGCCGTGGCCGGACGGCTATGCATGGCTGTGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAAAGGAATATCAAATCCCGGCAGGGGGAAATCGTTTTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGTTGCTGAAAAATGGCGTATTGCTGTCATTGCAGGCAGTGGACGGTAAAGACAG
ACAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGTCAGCTTCTTTTGCAGCAGAAAA
ACTGGGCGAGATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT148536 WP_004249771.1 NZ_CP047929:2757225-2757482 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT148536 NZ_CP063773:2144296-2144562 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGGGGTATGCGTGAGTTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTACGACACACTCAGTGACAGCGATAAGCGCACGTTTGTGCGCCTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCGAGCCGAAAGACGGAGAGCTGAAACGCATGATTTCTCTTATTCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: B4F0T8

Antitoxin

• AlphaFold DB: B4F0T9