Detailed information of TA system TA148535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1244838..1245483
• Replicon: chromosome
• Accession: NZ_CP047929
• Organism: Proteus mirabilis strain ChSC1905

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: GV833_RS05835
• Protein ID: WP_004247035.1
• Coordinates: 1244838..1245023 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GV833_RS05840
• Protein ID: WP_134736515.1
• Coordinates: 1245070..1245483 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV833_RS05805	1240078..1240305	+	228	WP_004247042.1	YejL family protein	-
GV833_RS05810	1240329..1242062	+	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
GV833_RS05820	1242469..1242783	+	315	WP_017628395.1	hypothetical protein	-
GV833_RS05825	1242847..1243398	+	552	WP_017628396.1	PH domain-containing protein	-
GV833_RS05830	1243957..1244727	-	771	Protein_1134	DUF1073 domain-containing protein	-
GV833_RS05835	1244838..1245023	+	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
GV833_RS05840	1245070..1245483	+	414	WP_134736515.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GV833_RS05845	1245579..1246079	+	501	WP_004247032.1	response regulator	-
GV833_RS05850	1246393..1246686	+	294	Protein_1138	LysE family transporter	-
GV833_RS05855	1246799..1247377	-	579	WP_161772320.1	alpha/beta hydrolase	-
GV833_RS05860	1248227..1248973	+	747	WP_012367749.1	class I SAM-dependent methyltransferase	-
GV833_RS05865	1249144..1249320	-	177	WP_004247793.1	hypothetical protein	-
GV833_RS05870	1249772..1249930	+	159	WP_004247025.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1235739..1250713	14974

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T148535 WP_004247035.1 NZ_CP047929:1244838-1245023 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T148535 NZ_CP063773:c1904276-1904025 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAGAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAATCCTGCGTGCTGATGTCTCTGGAAGAGTATAATTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15250.99 Da
• Isoelectric Point: 4.4531

>AT148535 WP_134736515.1 NZ_CP047929:1245070-1245483 [Proteus mirabilis]
MLYPAFIEIDENGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT148535 NZ_CP063773:c1904028-1903774 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGTAGAACACCTTTTGAGGGAAAAGGAAAACCGGAGCCACTTAAACATAACCTCGCTG
GTTTCTGGTCGCGCCGTATAACCGAAGAGCATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Structures

Toxin

• AlphaFold DB: B4ET86