Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2705042..2705556 Replicon chromosome
Accession NZ_CP047924
Organism Staphylococcus aureus strain SR130

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GWG03_RS13345 Protein ID WP_000581792.1
Coordinates 2705347..2705556 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GWG03_RS13340 Protein ID WP_000138932.1
Coordinates 2705042..2705335 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWG03_RS13320 (2700205) 2700205..2700846 + 642 WP_000483153.1 thiamine phosphate synthase -
GWG03_RS13325 (2700932) 2700932..2701804 + 873 WP_000725802.1 membrane protein insertase YidC -
GWG03_RS13330 (2702717) 2702717..2703364 - 648 WP_001187630.1 HD domain-containing protein -
GWG03_RS13335 (2703392) 2703392..2704876 - 1485 WP_000571549.1 cardiolipin synthase -
GWG03_RS13340 (2705042) 2705042..2705335 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GWG03_RS13345 (2705347) 2705347..2705556 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
GWG03_RS13350 (2705684) 2705684..2705821 + 138 WP_000828354.1 Lmo0850 family protein -
GWG03_RS13355 (2706085) 2706085..2707287 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
GWG03_RS13360 (2707605) 2707605..2708675 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
GWG03_RS13365 (2708690) 2708690..2710048 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148533 WP_000581792.1 NZ_CP047924:2705347-2705556 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148533 NZ_CP063773:1854622-1855956 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGCCTCGAACACAACAGCGCTTAGCGATATGGATGAACGGGATCCAAGTTGGATTTTGGGAAAAGACCAGAGGCGAAGA
TAGGTTGCAATACCTTCCCGAATGGATTGCTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAGCTTTGGCGCGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCAACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGGAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTGAAGTATCGCCCGCTTTGTGACGCTGAGATCGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCTGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAGGACAATGGTGCTTGCCAGAAGGAAGTACCCCAACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTATGTTCTTTGATCC
TTAAGGAATATGGGATTCCTGTCGCAAAAACGCAAATTGCACAGTTTGAAGAGCAGAAGGCACTGGTTGTTGAGCGTTTT
GACAGAAGATGGTCAAGCGATCGGCAATGGGTCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGGCCGGGGATTTCCGATATTATGACCATACTGAGTCATTCAGAGCAGGCTGGGC
AGGATAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCACTTTATGATGTTTTATCGGCATGGCCTGTCATTGGTCCGTG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGCAGTAATTATTACCATTTGTACAGAA
TTAAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGCAGACGACAGGTTGAAGCCATGATGGATGATATT
ATATCCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCCCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCACCGTAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148533 WP_000138932.1 NZ_CP047924:2705042-2705335 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148533 NZ_CP063773:1854312-1854617 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGGTGATTGGCTTTCGCAAAGCTAAGGGGCTGAC
GCAAAAAGATGTGTCTGAAAGGTTAGGTGTAACACAGCAAACCTATGCCCGCTTGGAAGCAAACCCCGGCAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTTACTGTTCTGGGGGTTGAGGTGGTGCTGTCTTCTGGACCAAACGTACATTTCTCTATG
TCATCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References