Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2329599..2330122 Replicon chromosome
Accession NZ_CP047924
Organism Staphylococcus aureus strain SR130

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag GWG03_RS11400 Protein ID WP_000074049.1
Coordinates 2329856..2330122 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag GWG03_RS11395 Protein ID WP_000587616.1
Coordinates 2329599..2329856 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWG03_RS11380 (2326096) 2326096..2326845 - 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -
GWG03_RS11385 (2327040) 2327040..2328617 + 1578 WP_103147947.1 FMN-binding glutamate synthase family protein -
GWG03_RS11390 (2328785) 2328785..2329240 - 456 WP_000732076.1 DUF1307 domain-containing protein -
GWG03_RS11395 (2329599) 2329599..2329856 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GWG03_RS11400 (2329856) 2329856..2330122 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
GWG03_RS11405 (2330477) 2330477..2331553 + 1077 WP_001076673.1 M42 family metallopeptidase -
GWG03_RS11410 (2331801) 2331801..2332463 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
GWG03_RS11415 (2332456) 2332456..2333232 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
GWG03_RS11420 (2333628) 2333628..2334815 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T148525 WP_000074049.1 NZ_CP047924:2329856-2330122 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148525 NZ_CP063772:c2207556-2207254 [Lysobacter sp. H21R4]
ATGGCTGAAATAGTCTGGACGGAGCCTGCGCTTGGCGATCTGGATGCGATCGCGGACTACATCGCGTTGGAGGATCCGGT
CGCTGCCTCGGAGCTGGTCAAGCGCGTCCTGGCGCATGGCGAGCAGCTGGCCGACCATCCTGAAAGCGGTAGCCGTCCGG
CGGAACTGGGGCGTTCGCGGTATCGGCAGGTTGTCGATCCGCCGTGTCGGGTGTTCCATCGCTACGACGGACAGACCGTG
TTCGTCCTTTACGTGATGCGCACTGAGCGCCTGCTTCGCAAGGGGCAGCTGACCTCCGTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT148525 WP_000587616.1 NZ_CP047924:2329599-2329856 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148525 NZ_CP063772:c2207801-2207544 [Lysobacter sp. H21R4]
ATGCGTACCGAACTCGTCACCACCCTCAAGCGCCAGGCGACTGAACTGCTCTCTGACATCGCGCGGGACAAGGAGCCCAT
CCTCATCACGCAACACGGCTTGCCAAGTGCGTATCTGGTGGACGTCGAGAGCTTCCAGCTCATGCAACAGCGGATGGCGG
TGCTTGAGGGCATTGCACGTGGTGAGCAGGCGATTGCCGAGAGCCGTGTTGTCACTCATGCGCAAGCCCGGAAGCGCCTC
GCCCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References