Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1179512..1180300 | Replicon | chromosome |
| Accession | NZ_CP047924 | ||
| Organism | Staphylococcus aureus strain SR130 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2C9TYR5 |
| Locus tag | GWG03_RS05945 | Protein ID | WP_001573840.1 |
| Coordinates | 1179839..1180300 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | GWG03_RS05940 | Protein ID | WP_000333630.1 |
| Coordinates | 1179512..1179826 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GWG03_RS05880 (1174589) | 1174589..1175362 | - | 774 | WP_001288248.1 | AAA family ATPase | - |
| GWG03_RS05885 (1175362) | 1175362..1175841 | - | 480 | WP_021286127.1 | siphovirus Gp157 family protein | - |
| GWG03_RS05890 (1175856) | 1175856..1176116 | - | 261 | WP_001644876.1 | DUF1108 family protein | - |
| GWG03_RS05895 (1176097) | 1176097..1176426 | - | 330 | WP_000138304.1 | hypothetical protein | - |
| GWG03_RS05900 (1176516) | 1176516..1176677 | - | 162 | WP_000066017.1 | DUF1270 domain-containing protein | - |
| GWG03_RS05905 (1176670) | 1176670..1176891 | - | 222 | WP_000977378.1 | hypothetical protein | - |
| GWG03_RS05910 (1176962) | 1176962..1177207 | + | 246 | WP_000122246.1 | hypothetical protein | - |
| GWG03_RS05915 (1177175) | 1177175..1177378 | - | 204 | Protein_1141 | hypothetical protein | - |
| GWG03_RS05920 (1177394) | 1177394..1178146 | - | 753 | WP_001148634.1 | phage antirepressor KilAC domain-containing protein | - |
| GWG03_RS05925 (1178148) | 1178148..1178333 | - | 186 | WP_000933363.1 | helix-turn-helix transcriptional regulator | - |
| GWG03_RS14225 (1178776) | 1178776..1178910 | + | 135 | WP_260648415.1 | hypothetical protein | - |
| GWG03_RS05930 (1178907) | 1178907..1179110 | - | 204 | WP_000394020.1 | hypothetical protein | - |
| GWG03_RS05935 (1179124) | 1179124..1179360 | - | 237 | WP_001121116.1 | helix-turn-helix transcriptional regulator | - |
| GWG03_RS05940 (1179512) | 1179512..1179826 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| GWG03_RS05945 (1179839) | 1179839..1180300 | + | 462 | WP_001573840.1 | phage protein | Toxin |
| GWG03_RS05950 (1180318) | 1180318..1180824 | + | 507 | WP_053504575.1 | hypothetical protein | - |
| GWG03_RS05955 (1180886) | 1180886..1181935 | + | 1050 | WP_001145728.1 | tyrosine-type recombinase/integrase | - |
| GWG03_RS05960 (1182003) | 1182003..1183400 | - | 1398 | WP_001074405.1 | Fe-S cluster assembly protein SufB | - |
| GWG03_RS05965 (1183551) | 1183551..1184015 | - | 465 | WP_001010508.1 | SUF system NifU family Fe-S cluster assembly protein | - |
| GWG03_RS05970 (1184005) | 1184005..1185255 | - | 1251 | WP_001006450.1 | cysteine desulfurase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1133417..1183400 | 49983 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18060.43 Da Isoelectric Point: 4.6915
>T148523 WP_001573840.1 NZ_CP047924:1179839-1180300 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T148523 NZ_CP063771:6914-7258 [Acinetobacter sp. Ac-14]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAATAACACAAGAGAAAGTCTTAGC
TGCGTTGGTTGTTCTGCAACTGCAAGGACCAAGTTTAGGTCGTCCCTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGAGGTAAACCATTAAGAGCATTTTTTGCATTCGATCCATTACGACAAGCAATT
GTACTGTGTATTGGTGATAAGAGCGGTAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATAAGCAATATGAACT
TCATCTCTCAACATTAGGAGAATAA
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAATAACACAAGAGAAAGTCTTAGC
TGCGTTGGTTGTTCTGCAACTGCAAGGACCAAGTTTAGGTCGTCCCTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGAGGTAAACCATTAAGAGCATTTTTTGCATTCGATCCATTACGACAAGCAATT
GTACTGTGTATTGGTGATAAGAGCGGTAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATAAGCAATATGAACT
TCATCTCTCAACATTAGGAGAATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT148523 WP_000333630.1 NZ_CP047924:1179512-1179826 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT148523 NZ_CP063771:7263-7565 [Acinetobacter sp. Ac-14]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCTGAGAGCCAAGCCCGTATTCAAAAAATGGCTGATGAATT
GCTATTAGAAAATCAGCTTTACCTTATTCGTGAAGAACTCGAAATCTCTCAAAAAGAACTGGCTGAAACTTTGGGAATAA
AACAGCCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAAGCTATG
GGAGGAAAGCTCCGTATTGATGTGGAACTTCCAACTGGGAAACATATAGGATTCAATGTATAG
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCTGAGAGCCAAGCCCGTATTCAAAAAATGGCTGATGAATT
GCTATTAGAAAATCAGCTTTACCTTATTCGTGAAGAACTCGAAATCTCTCAAAAAGAACTGGCTGAAACTTTGGGAATAA
AACAGCCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAAGCTATG
GGAGGAAAGCTCCGTATTGATGTGGAACTTCCAACTGGGAAACATATAGGATTCAATGTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2C9TYR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |