Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2796021..2796535 Replicon chromosome
Accession NZ_CP047922
Organism Staphylococcus aureus strain SR231

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GWG04_RS13905 Protein ID WP_000581792.1
Coordinates 2796326..2796535 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GWG04_RS13900 Protein ID WP_000138932.1
Coordinates 2796021..2796314 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWG04_RS13880 (2791184) 2791184..2791825 + 642 WP_000483153.1 thiamine phosphate synthase -
GWG04_RS13885 (2791911) 2791911..2792783 + 873 WP_000725802.1 membrane protein insertase YidC -
GWG04_RS13890 (2793696) 2793696..2794343 - 648 WP_001187630.1 HD domain-containing protein -
GWG04_RS13895 (2794371) 2794371..2795855 - 1485 WP_000571549.1 cardiolipin synthase -
GWG04_RS13900 (2796021) 2796021..2796314 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GWG04_RS13905 (2796326) 2796326..2796535 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
GWG04_RS13910 (2796663) 2796663..2796800 + 138 WP_000828354.1 Lmo0850 family protein -
GWG04_RS13915 (2797064) 2797064..2798266 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
GWG04_RS13920 (2798584) 2798584..2799654 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
GWG04_RS13925 (2799669) 2799669..2801027 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148515 WP_000581792.1 NZ_CP047922:2796326-2796535 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148515 NZ_CP063766:1128422-1128688 [Enterococcus lactis]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGATGCTGATCGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATAAACAATTGGTTGTTATCGCTATTCAAGTA
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148515 WP_000138932.1 NZ_CP047922:2796021-2796314 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148515 NZ_CP063766:1128195-1128425 [Enterococcus lactis]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGAAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCTATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References