Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2404603..2405126 Replicon chromosome
Accession NZ_CP047922
Organism Staphylococcus aureus strain SR231

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag GWG04_RS11890 Protein ID WP_000074049.1
Coordinates 2404860..2405126 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag GWG04_RS11885 Protein ID WP_000587616.1
Coordinates 2404603..2404860 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWG04_RS11870 (2401100) 2401100..2401849 - 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -
GWG04_RS11875 (2402044) 2402044..2403621 + 1578 WP_103147947.1 FMN-binding glutamate synthase family protein -
GWG04_RS11880 (2403789) 2403789..2404244 - 456 WP_000732076.1 DUF1307 domain-containing protein -
GWG04_RS11885 (2404603) 2404603..2404860 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GWG04_RS11890 (2404860) 2404860..2405126 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
GWG04_RS11895 (2405481) 2405481..2406557 + 1077 WP_001076673.1 M42 family metallopeptidase -
GWG04_RS11900 (2406805) 2406805..2407467 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
GWG04_RS11905 (2407460) 2407460..2408236 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
GWG04_RS11910 (2408632) 2408632..2409819 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T148507 WP_000074049.1 NZ_CP047922:2404860-2405126 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148507 NZ_CP063759:c5479707-5479324 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT148507 WP_000587616.1 NZ_CP047922:2404603-2404860 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148507 NZ_CP063759:c5479949-5479707 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References