Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 4576728..4577254 Replicon chromosome
Accession NZ_CP047898
Organism Pseudarthrobacter sp. YJ56

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GU243_RS21525 Protein ID WP_160678186.1
Coordinates 4576928..4577254 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GU243_RS21520 Protein ID WP_160679458.1
Coordinates 4576728..4576931 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GU243_RS21500 4572142..4573037 + 896 Protein_4249 class I SAM-dependent methyltransferase -
GU243_RS21505 4573224..4573715 + 492 WP_160678180.1 nucleoside deaminase -
GU243_RS21510 4573911..4574420 - 510 WP_160678182.1 hypothetical protein -
GU243_RS21515 4574862..4576328 - 1467 WP_160678184.1 hypothetical protein -
GU243_RS21520 4576728..4576931 + 204 WP_160679458.1 DUF3018 family protein Antitoxin
GU243_RS21525 4576928..4577254 + 327 WP_160678186.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GU243_RS21530 4577416..4577835 - 420 WP_160678188.1 DUF4862 family protein -
GU243_RS21535 4577936..4578229 - 294 Protein_4256 HNH endonuclease -
GU243_RS21540 4578278..4578829 + 552 WP_160678190.1 hypothetical protein -
GU243_RS21545 4578852..4580036 - 1185 WP_160678192.1 cation:proton antiporter -
GU243_RS21550 4580076..4580471 - 396 WP_160678194.1 hypothetical protein -
GU243_RS21555 4580464..4581036 - 573 WP_160678195.1 SRPBCC family protein -
GU243_RS21560 4581250..4581432 - 183 WP_160678197.1 hypothetical protein -
GU243_RS21565 4581522..4581896 - 375 WP_160678199.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-106)

Antitoxin

Antitoxin MazE-like

(4-65)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11746.66 Da        Isoelectric Point: 7.1652

>T148497 WP_160678186.1 NZ_CP047898:4576928-4577254 [Pseudarthrobacter sp. YJ56]
VNRGDLWTVYGGTCAQKPRPALIIQDDLFAESHSVTLLPLTTHLTDAPLLRLTVDPGPLIGLQSISQIMVDKLTTVRRAN
LGQRIGRIDSETMVAVEQSLAVFLGLAR

Download         Length: 327 bp

>T148497 NZ_CP063759:329445-329813 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7943.78 Da        Isoelectric Point: 4.8232

>AT148497 WP_160679458.1 NZ_CP047898:4576728-4576931 [Pseudarthrobacter sp. YJ56]
ISVRDRVARHRVALRERELRQIQMWVPDARTEEFRREAQRQALAVAAADRPGDDQDFVDQVSEDWPE

Download         Length: 204 bp

>AT148497 NZ_CP063759:329227-329448 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References