Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1000045..1001279 Replicon chromosome
Accession NZ_CP047883
Organism Streptococcus mitis strain S022-V3-A4

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag M594_RS04960 Protein ID WP_173876117.1
Coordinates 1000521..1001279 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag M594_RS04955 Protein ID WP_000579619.1
Coordinates 1000045..1000521 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M594_RS04905 995279..995563 + 285 WP_000969641.1 hypothetical protein -
M594_RS04910 995577..995873 + 297 WP_000998891.1 hypothetical protein -
M594_RS04915 995887..996084 - 198 WP_004249782.1 hypothetical protein -
M594_RS04920 996244..996885 + 642 WP_000933082.1 hypothetical protein -
M594_RS04925 996895..997980 + 1086 WP_173876116.1 toprim domain-containing protein -
M594_RS04930 998031..998264 + 234 WP_000152419.1 hypothetical protein -
M594_RS04935 998261..998644 + 384 WP_000159216.1 hypothetical protein -
M594_RS04940 998685..998960 + 276 WP_000495442.1 hypothetical protein -
M594_RS04945 999042..999674 + 633 WP_000424174.1 DUF3990 domain-containing protein -
M594_RS04950 999665..999892 + 228 WP_000301902.1 hypothetical protein -
M594_RS04955 1000045..1000521 + 477 WP_000579619.1 helix-turn-helix domain-containing protein Antitoxin
M594_RS04960 1000521..1001279 + 759 WP_173876117.1 zeta toxin family protein Toxin
M594_RS04965 1001675..1002571 - 897 WP_050088029.1 tyrosine-type recombinase/integrase -
M594_RS04970 1002662..1003303 + 642 Protein_927 glycine hydroxymethyltransferase -
M594_RS04975 1003303..1003704 + 402 Protein_928 C40 family peptidase -
M594_RS04980 1003701..1004633 + 933 WP_001224318.1 conjugal transfer protein -
M594_RS04985 1004878..1004994 + 117 WP_001814923.1 tetracycline resistance determinant leader peptide -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element mef(A) / msr(D) / tet(M) - 963597..1027056 63459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 29058.03 Da        Isoelectric Point: 7.5460

>T148492 WP_173876117.1 NZ_CP047883:1000521-1001279 [Streptococcus mitis]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDSREDKISAADILQELLFGEWSQVEKEML
KSGEERFKDLTN

Download         Length: 759 bp

>T148492 NZ_CP063747:c4918789-4917872 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGTGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18231.66 Da        Isoelectric Point: 4.4188

>AT148492 WP_000579619.1 NZ_CP047883:1000045-1000521 [Streptococcus mitis]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT148492 NZ_CP063747:c4919553-4918795 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References