Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 48630..49273 Replicon plasmid pESI
Accession NZ_CP047882
Organism Salmonella enterica subsp. enterica serovar Infantis strain 119944

Toxin (Protein)


Gene name vagD Uniprot ID A0A5T8FJ24
Locus tag GVI52_RS23060 Protein ID WP_023994137.1
Coordinates 48630..49046 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5T3Q059
Locus tag GVI52_RS23065 Protein ID WP_023994136.1
Coordinates 49043..49273 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI52_RS23030 44110..44901 + 792 WP_023994142.1 F4 (K88) fimbria minor subunit FaeH -
GVI52_RS23035 44929..45693 + 765 WP_023994141.1 minor fimbrial protein -
GVI52_RS23040 45896..46486 + 591 WP_023994140.1 hypothetical protein -
GVI52_RS23045 46552..46764 + 213 WP_023994139.1 PefI -
GVI52_RS23050 47025..47186 + 162 WP_001816720.1 hypothetical protein -
GVI52_RS23055 47212..48060 + 849 WP_023994138.1 SdiA-regulated domain-containing protein -
GVI52_RS23060 48630..49046 - 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin Toxin
GVI52_RS23065 49043..49273 - 231 WP_023994136.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GVI52_RS23070 49897..50115 + 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA -
GVI52_RS23075 50117..50422 + 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB -
GVI52_RS23080 50424..50714 + 291 WP_023994133.1 hypothetical protein -
GVI52_RS23085 50711..51061 + 351 Protein_58 3'-5' exonuclease -
GVI52_RS23090 51087..51173 + 87 Protein_59 cytoplasmic protein -
GVI52_RS23095 51163..51878 - 716 Protein_60 transposase -
GVI52_RS23100 53160..53696 + 537 WP_023994130.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..285081 285081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T148490 WP_023994137.1 NZ_CP047882:c49046-48630 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T148490 NZ_CP063747:c4660128-4659595 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT148490 WP_023994136.1 NZ_CP047882:c49273-49043 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT148490 NZ_CP063747:c4660405-4660139 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FJ24

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q059

References