Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 28611..29368 Replicon plasmid pESI
Accession NZ_CP047882
Organism Salmonella enterica subsp. enterica serovar Infantis strain 119944

Toxin (Protein)


Gene name tacT Uniprot ID A0A241PXX4
Locus tag GVI52_RS22935 Protein ID WP_023994162.1
Coordinates 28886..29368 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A727Z1I8
Locus tag GVI52_RS22930 Protein ID WP_001195098.1
Coordinates 28611..28895 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI52_RS22885 24431..24598 - 168 WP_023994170.1 IS66 family insertion sequence element accessory protein TnpB -
GVI52_RS22890 24585..24914 - 330 WP_023994169.1 IS66 family insertion sequence hypothetical protein -
GVI52_RS22895 25047..25891 + 845 Protein_20 site-specific tyrosine recombinase XerC -
GVI52_RS22900 25860..26147 + 288 WP_031619580.1 damage-inducible protein J -
GVI52_RS22905 26144..26449 + 306 WP_023994167.1 type II toxin-antitoxin system RelE/ParE family toxin -
GVI52_RS22910 27036..27462 + 427 Protein_23 DUF977 family protein -
GVI52_RS22915 27488..27823 + 336 WP_023994164.1 hypothetical protein -
GVI52_RS22920 28045..28323 - 279 WP_023994163.1 PIN domain-containing protein -
GVI52_RS22925 28366..28440 + 75 Protein_26 helix-turn-helix domain-containing protein -
GVI52_RS22930 28611..28895 + 285 WP_001195098.1 DUF1778 domain-containing protein Antitoxin
GVI52_RS22935 28886..29368 + 483 WP_023994162.1 GNAT family N-acetyltransferase Toxin
GVI52_RS22940 29683..30109 + 427 Protein_29 transposase -
GVI52_RS22945 30426..30635 + 210 WP_023994160.1 hemolysin expression modulator Hha -
GVI52_RS22950 30709..31061 - 353 Protein_31 transposase -
GVI52_RS22955 31288..32261 + 974 Protein_32 IS256 family transposase -
GVI52_RS22960 32263..32505 + 243 WP_023994156.1 hypothetical protein -
GVI52_RS22965 32576..33532 + 957 WP_023994155.1 Rpn family recombination-promoting nuclease/putative transposase -
GVI52_RS22970 33576..33803 + 228 WP_072205048.1 hypothetical protein -
GVI52_RS22975 33845..34096 - 252 WP_023994153.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..285081 285081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 20654.05 Da        Isoelectric Point: 13.0041

>T148489 WP_023994162.1 NZ_CP047882:28886-29368 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Download         Length: 483 bp

>T148489 NZ_CP063747:4047307-4047525 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 12194.55 Da        Isoelectric Point: 12.7731

>AT148489 WP_001195098.1 NZ_CP047882:28611-28895 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Download         Length: 285 bp

>AT148489 NZ_CP063747:4046906-4047280 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXX4

Antitoxin

Source ID Structure
AlphaFold DB A0A727Z1I8

References