Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 793018..793852 Replicon chromosome
Accession NZ_CP047876
Organism Escherichia coli strain LD22-1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GUU87_RS03830 Protein ID WP_021527014.1
Coordinates 793018..793395 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GUU87_RS03835 Protein ID WP_032261140.1
Coordinates 793484..793852 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU87_RS03795 788295..788900 + 606 WP_001255030.1 type II secretion system minor pseudopilin GspJ -
GUU87_RS03800 788897..789874 + 978 WP_000633239.1 type II secretion system minor pseudopilin GspK -
GUU87_RS03805 789871..791049 + 1179 WP_000094989.1 type II secretion system protein GspL -
GUU87_RS03810 791051..791587 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
GUU87_RS03815 791954..792514 - 561 Protein_745 DUF4942 domain-containing protein -
GUU87_RS03820 792599..792796 - 198 WP_089078746.1 DUF957 domain-containing protein -
GUU87_RS03825 792872..793021 - 150 Protein_747 hypothetical protein -
GUU87_RS03830 793018..793395 - 378 WP_021527014.1 type IV toxin-antitoxin system toxin CbtA Toxin
GUU87_RS03835 793484..793852 - 369 WP_032261140.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GUU87_RS03840 793926..794147 - 222 WP_000692320.1 DUF987 domain-containing protein -
GUU87_RS03845 794210..794686 - 477 WP_032261139.1 RadC family protein -
GUU87_RS03850 794702..795187 - 486 WP_021526886.1 antirestriction protein -
GUU87_RS03855 795278..796096 - 819 WP_032261137.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14010.13 Da        Isoelectric Point: 9.1378

>T148456 WP_021527014.1 NZ_CP047876:c793395-793018 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLGQHYGLTLDDTPFADERVIEQHIKAGISLCDAVNFLVEKYTLVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEVKR

Download         Length: 378 bp

>T148456 NZ_CP063658:c2181005-2180691 [Lysobacter sp. H23M47]
ATGGCTGAAATAGTCTGGACAGCGCCCGCGCTGAGCGATCTGGATGCGATCGCGGATTACATCGCGTTGGAGGATCCGGT
CGCGGCATCGGAACTGGTCAAGCGCGTCCTCGCTCATGTCGAGCAGCTGGCGGACCATCCTGAAAGCGGTAGCCGCCCGG
CGGAACTGGGGCGTTCGCGGTATCGGCAGGTTGTCGAGCCGCCGTGCCGGGTGTTCTATCGCTACGACGGACAGACCGTG
TTCGTCCTTTACGTGATGCGCACTGAGCGTCTGCTTCGGAAGGCGCAGCTGACCTCAAGGACCCCGCAGAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.60 Da        Isoelectric Point: 6.6209

>AT148456 WP_032261140.1 NZ_CP047876:c793852-793484 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT148456 NZ_CP063658:c2181250-2180993 [Lysobacter sp. H23M47]
ATGCGTACCGAACTCGTCACCACCCTCAAGCGCCAGGCGACTGAACTGCTCTCTGACATCGAGCGGGACAAGGAGCCCAT
CCTCATCACGCAACACGGCCTGCCGAGTGCGTATCTGGTGGACGTCGAGAGCTACCAGCTCATGCAGCAGCGGATGGCGG
TGCTTGAGGGCATTGCCCGCGGTGAACAGGCGATTGCCGAGAGCCGTGTTGTCACTCACGCGCAAGCCCGGAAGCGCCTC
GCCCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References