Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2348799..2349322 Replicon chromosome
Accession NZ_CP047867
Organism Staphylococcus aureus strain UP_419

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag E3S59_RS11490 Protein ID WP_000074049.1
Coordinates 2349056..2349322 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E3S59_RS11485 Protein ID WP_000587616.1
Coordinates 2348799..2349056 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S59_RS11470 2345296..2346045 - 750 WP_000072461.1 CPBP family intramembrane metalloprotease -
E3S59_RS11475 2346240..2347817 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
E3S59_RS11480 2347985..2348440 - 456 WP_000732076.1 DUF1307 domain-containing protein -
E3S59_RS11485 2348799..2349056 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S59_RS11490 2349056..2349322 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
E3S59_RS11495 2349677..2350753 + 1077 WP_001076673.1 M42 family metallopeptidase -
E3S59_RS11500 2351001..2351663 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
E3S59_RS11505 2351656..2352432 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
E3S59_RS11510 2352828..2354015 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T148444 WP_000074049.1 NZ_CP047867:2349056-2349322 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148444 NZ_CP063518:c2639777-2639674 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT148444 WP_000587616.1 NZ_CP047867:2348799-2349056 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148444 NZ_CP063518:2639636-2639907 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References