Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1253675..1254152 Replicon chromosome
Accession NZ_CP047865
Organism Staphylococcus aureus strain UP_844

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S61_RS06475 Protein ID WP_000052076.1
Coordinates 1253964..1254152 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S61_RS06470 Protein ID WP_001059690.1
Coordinates 1253675..1253935 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S61_RS06435 1249068..1249784 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3S61_RS06440 1249932..1250354 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S61_RS06445 1250753..1251247 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S61_RS06450 1251402..1252019 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3S61_RS06455 1252092..1252673 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S61_RS06460 1252898..1253134 + 237 WP_000349581.1 hypothetical protein -
E3S61_RS06465 1253131..1253334 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S61_RS06470 1253675..1253935 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S61_RS06475 1253964..1254152 + 189 WP_000052076.1 hypothetical protein Toxin
E3S61_RS06480 1254340..1254909 + 570 WP_001106658.1 hypothetical protein -
E3S61_RS06485 1254997..1255281 + 285 WP_001004399.1 hypothetical protein -
E3S61_RS06490 1255343..1255561 + 219 WP_000005886.1 hypothetical protein -
E3S61_RS06495 1256053..1256253 - 201 WP_001059082.1 cold-shock protein -
E3S61_RS06500 1256610..1257296 - 687 WP_000141557.1 thermonuclease family protein -
E3S61_RS06505 1257637..1258158 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-44)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148426 WP_000052076.1 NZ_CP047865:1253964-1254152 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148426 NZ_CP063516:20611-20745 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148426 WP_001059690.1 NZ_CP047865:1253675-1253935 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148426 NZ_CP063516:c20566-20506 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References