Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2348437..2348960 Replicon chromosome
Accession NZ_CP047863
Organism Staphylococcus aureus strain UP_1106

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag E3S63_RS11550 Protein ID WP_000074049.1
Coordinates 2348694..2348960 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E3S63_RS11545 Protein ID WP_000587616.1
Coordinates 2348437..2348694 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S63_RS11530 2344934..2345683 - 750 WP_000072461.1 CPBP family intramembrane metalloprotease -
E3S63_RS11535 2345878..2347455 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
E3S63_RS11540 2347623..2348078 - 456 WP_000732076.1 DUF1307 domain-containing protein -
E3S63_RS11545 2348437..2348694 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S63_RS11550 2348694..2348960 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
E3S63_RS11555 2349315..2350391 + 1077 WP_001076673.1 M42 family metallopeptidase -
E3S63_RS11560 2350639..2351301 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
E3S63_RS11565 2351294..2352070 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
E3S63_RS11570 2352466..2353653 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T148410 WP_000074049.1 NZ_CP047863:2348694-2348960 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148410 NZ_CP063515:c1518679-1518527 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT148410 WP_000587616.1 NZ_CP047863:2348437-2348694 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148410 NZ_CP063515:1518731-1518791 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References