148402

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2779251..2779780 Replicon chromosome
Accession NZ_CP047861
Organism Staphylococcus aureus strain UP_1322

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3S64_RS13835 Protein ID WP_000621175.1
Coordinates 2779418..2779780 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S64_RS13830 Protein ID WP_000948331.1
Coordinates 2779251..2779421 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S64_RS13800 2774288..2774848 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
E3S64_RS13805 2775056..2775535 + 480 WP_001287087.1 hypothetical protein -
E3S64_RS13810 2775528..2777111 + 1584 WP_001294626.1 PH domain-containing protein -
E3S64_RS13815 2777098..2777589 + 492 WP_001205912.1 PH domain-containing protein -
E3S64_RS13820 2777593..2777952 + 360 WP_000581197.1 holo-ACP synthase -
E3S64_RS13825 2778018..2779166 + 1149 WP_160195276.1 alanine racemase -
E3S64_RS13830 2779251..2779421 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S64_RS13835 2779418..2779780 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S64_RS13840 2780130..2781131 + 1002 WP_000390827.1 PP2C family protein-serine/threonine phosphatase -
E3S64_RS13845 2781250..2781576 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3S64_RS13850 2781578..2782057 + 480 WP_001190829.1 anti-sigma B factor RsbW -
E3S64_RS13855 2782032..2782802 + 771 WP_001041111.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T148402 WP_000621175.1 NZ_CP047861:2779418-2779780 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T148402 NZ_CP063511:3734800-3734907 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT148402 WP_000948331.1 NZ_CP047861:2779251-2779421 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT148402 NZ_CP063511:c3734753-3734687 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References