148392

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1243837..1244314 Replicon chromosome
Accession NZ_CP047861
Organism Staphylococcus aureus strain UP_1322

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S64_RS06415 Protein ID WP_000052076.1
Coordinates 1244126..1244314 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S64_RS06410 Protein ID WP_001059690.1
Coordinates 1243837..1244097 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S64_RS06375 1239230..1239946 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3S64_RS06380 1240094..1240516 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S64_RS06385 1240915..1241409 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S64_RS06390 1241564..1242181 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3S64_RS06395 1242254..1242835 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S64_RS06400 1243060..1243296 + 237 WP_000349581.1 hypothetical protein -
E3S64_RS06405 1243293..1243496 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S64_RS06410 1243837..1244097 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S64_RS06415 1244126..1244314 + 189 WP_000052076.1 hypothetical protein Toxin
E3S64_RS06420 1244502..1245071 + 570 WP_001106658.1 hypothetical protein -
E3S64_RS06425 1245159..1245443 + 285 WP_001004399.1 hypothetical protein -
E3S64_RS06430 1245505..1245723 + 219 WP_000005886.1 hypothetical protein -
E3S64_RS06435 1246215..1246415 - 201 WP_001059082.1 cold-shock protein -
E3S64_RS06440 1246772..1247458 - 687 WP_000141557.1 thermonuclease family protein -
E3S64_RS06445 1247799..1248320 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148392 WP_000052076.1 NZ_CP047861:1244126-1244314 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148392 NZ_CP063511:c1868153-1867776 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148392 WP_001059690.1 NZ_CP047861:1243837-1244097 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148392 NZ_CP063511:c1868574-1868200 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References